Sentences with phrase «treatment of aggressive cancers»

More precise dosing methods and cellular engineering techniques show promise in the effort to improve treatment of aggressive cancers with personalized cellular therapies, according to new studies from researchers in the Perelman School of Medicine and the Abramson Cancer Center at the University of Pennsylvania and The Children's Hospital of Philadelphia.

Not exact matches

In clinical trials the treatment — which involves extracting individual patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.

Swiss pharmaceutical giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

giant Novartis has made waves with a drug pipeline that includes one of the most talked - about experimental cancer therapies in recent years — a treatment called Kymriah that reconfigures the body's own immune cells to become aggressive blood - cancer killers.

As he battles brain cancer and the debilitating side effects of his aggressive treatment, McCain himself is reckoning with his history and the future, as he and a stream of friends share memories and say what needs to be said.

There is at least one approved device and scores of experimental treatments being tested that could improve the odds of longer - term survival for patients with the type of extremely aggressive brain cancer afflicting U.S. Sen. John McCain.

Medical opinion also varies on how the kind of breast cancer Lee had, a noninvasive form called ductal carcinoma in situ, should be treated, but Lee is adamant about early mammograms and aggressive treatment.

Bob Adair, 61, a carpenter for the Department of Sanitation, said losing his paid days off was a hardship after his wife underwent shoulder surgery and he had treatment for an aggressive form of prostate cancer.

The triggering of PARP enables cancer cells to withstand anti-hormone therapy treatment, causing cells to cultivate and develop into a more aggressive form.

For a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourish.

«Our discovery of these mutations is a first step in developing a genetics - based system for classifying endometriosis so that clinicians can sort out which forms of the disorder may need more aggressive treatment and which may not,» says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the Department of Gynecology & Obstetrics at the Johns Hopkins University School of Medicine and co-director of the Breast and Ovarian Cancer Program at the Johns Hopkins Kimmel Cancer Center.

«Markers for prostate cancer death can identify men in need of more aggressive treatment.»

Current treatments for acute lymphoblastic leukemia (ALL), an aggressive form of blood cancer, include conventional chemotherapy drugs that inhibit DNA synthesis.

Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

With the release and aggressive marketing of the long - acting narcotic OxyContin in 1996, a class of drugs that had largely been reserved for cancer patients was becoming a go - to treatment for conditions such as lower back pain.

Now, immunotherapy — a type of treatment that harnesses the patient's immune system to combat the disease — represents the future of cancer treatment, with its efficacy being demonstrated in even the most aggressive types of cancer.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

«This study demonstrates that targeted fusion - guided biopsy could significantly enhance our ability to identify patients with high - risk prostate cancers that need more aggressive treatment,» says lead author Mohummad Minhaj Siddiqui, MD, assistant professor of surgery at the University of Maryland School of Medicine and director of urologic robotic surgery at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

Patients with high levels of miR - 194 in their blood could receive more aggressive treatment to reduce the chance of the cancer spreading to other parts of the body.»

«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»

Together with clinical researchers, they are preparing treatments for glioblastoma — the most aggressive brain cancer in adults — , Friedreich's Ataxia — a hereditary neurodegenerative disease — , and a type of paediatric brain cancer.

Women who have a genetic mutation face a higher risk of developing a second breast cancer and may wish to consider more aggressive treatment, preventive measures or additional screening.

Few existing treatments offer durable survival benefits for patients whose NSCLC has spread past the lungs, due in part to the aggressive nature of lung cancer and its propensity to progress, even following treatment.

A Northwestern University - led study in the emerging field of nanocytology could one day help men make better decisions about whether or not to undergo aggressive prostate cancer treatments.

The Cancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tCancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tcancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.

Immunotherapy is a promising approach in the treatment of metastatic melanoma, an aggressive and deadly form of skin cancer; but for most patients, immunotherapy drugs so far have failed to live up to their promise and provide little or no benefit.

The cancer shot With a near - endless supply of patients willing to undergo novel treatments, cancer researchers have been among the most aggressive in experimenting with therapeutic vaccination.

«Emotional distress may motivate men with low - risk prostate cancer to choose more aggressive treatment, such as choosing surgery over active surveillance,» said UB's Heather Orom, the lead author on the study, published in the February issue of the Journal of Urology.

In the group of patients with aggressive, or high risk, prostate cancer, the average number of days from diagnosis to surgery or radiation treatment was 96 days for Caucasian patients, and 105 days for African American patients.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

Because of this lack of receptors, common cancer drugs can't «find» the cells, and doctors must treat the cancer with extremely aggressive and highly toxic treatment strategies,» said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.

Chemotherapy and other cancer treatments are supposed to get rid of the disease, but a new study finds they can elicit aggressive tumor growth instead, STAT reports today.

Two immunotherapy drugs currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of melanoma also show promise for treating a rare but aggressive form of papillary thyroid cancer.

Scientists are reporting a test which can predict which patients are most at risk from aggressive prostate cancer, and whether they suffer an increased chance of treatment failure.

An international study led by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in cancer cells that allows the disease to erupt again even after aggressive treatment.

The Decision Counseling Program © developed by Dr. Myers and colleagues differs from previous decision aids in that a nurse educator uses the program not only to provide information about options, but also to identify and weigh the importance of things that matter to the patient (e.g., worry about treatment side effects, concern about developing aggressive cancer).

The authors say it is plausible that smokers have pathologically more - aggressive tumors, or that smoking may decrease the efficacy of colorectal cancer treatment.

It's the first CAR - T therapy to come before the FDA, leading a pack of novel treatments that promise to change the standard of care for certain aggressive blood cancers.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

«In some cases, a low volume of less aggressive prostate cancer may not necessitate treatment, but even in those cases where a «treatment» is not performed in favor of active surveillance, the emotional distress of a cancer diagnosis shouldn't be underestimated,» Turini said.

They are hypothesized to be the cells that undergo cancerous transformation and cause Merkel cell carcinoma, an aggressive form of skin cancer with no effective treatment.

In addition, research continues to uncover new clues to identify which men are at highest risk of aggressive prostate cancer and could most benefit from screening and treatment.

In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.

We also know that cancers with low levels of WWOX tend to be more aggressive and less responsive to treatment,» says Professor Rob Richards, Head of Genetics and Evolution in the University's School of Biological Sciences.

The discovery offers a new treatment option beyond chemotherapy for this aggressive type of breast cancer.

But in both cases, tumors can become resistant to treatments — leading to the most challenging and aggressive types of those cancers.

Currently, cancer is present in one in 10 biopsies ordered by physicians, but all must be analyzed by pathologists to identify the extent and volume of the disease, determine if it has spread and whether the patient has an aggressive or indolent cancer and needs chemotherapy or a less drastic treatment.

Combined treatment with two cancer immunotherapy drugs — one a novel immune modulator and one that focuses and activates the antitumor immune response — significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.

Compared to other types of breast cancer, triple negative breast cancers are often more aggressive and have fewer treatment options.

This is the first population - based study to compare the follow - up intensity of American men with prostate cancer who have not undergone aggressive treatment with those who opted to undergo various forms of aggressive therapy, such as surgery and radiation.