Not exact matches
The team gave 137 women
with breast cancer either T - DM1 or the standard
treatment of Herceptin plus another drug,
docetaxel.
If prolongation of life was the primary therapeutic objective and the patients were eligible for
docetaxel treatment, the G - BA specified
docetaxel in combination
with prednisone or prednisolone as appropriate comparator therapy (
docetaxel population).
No evaluable data were available for the comparison
with docetaxel in patients in whom prolongation of life was the primary
treatment goal.
In the 520 patients who had high - extent disease (whose cancer had spread to major organs and / or the bones),
treatment with ADT plus
docetaxel had an even greater benefit: these men had a median overall survival of 49.2 months versus 32.2 in the ADT - only group — a difference of 17 months.
RNA - sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined
treatments of cisplatin
with paclitaxel and
docetaxel.
• The participant has received prior
treatment with gemcitabine or
docetaxel.
The drug's manufacturer, Roche, said trials in these patients have shown that giving pertuzumab in combination
with the drugs trastuzumab (Herceptin) and
docetaxel could extend survival by nearly 16 months compared to standard
treatment.
Pertuzumab was approved by the FDA in 2012 for first - line
treatment of HER2 + metastatic breast cancer in combination
with trastuzumab and the chemotherapy
docetaxel (Taxotere).