Sentences with phrase «treatments in animal models of the disease»

«We wanted to develop a newborn screen for NPC because we know that the earlier we intervene with investigational treatments in animal models of the disease, the longer the animals live,» said Ory, the Alan A. and Edith L. Wolff Distinguished Professor of Medicine.

Not exact matches

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioIn a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioin a mouse model of the neurodegenerative condition.

«We report here a gene therapy dose - finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue,» said Childers.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease

Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

Abstract: Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment.

There are currently no disease - modifying treatments that have been shown to slow the progression or delay the onset of HD in humans; however, several compounds have demonstrated promise in animal models of HD.1 Robust and sensitive markers of disease progression are required to assess their efficacy in humans.

Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.

An important step in developing effective treatments for human disease is finding an effective animal model of the disease to test potential therapies.

Although stem cell therapy is fairly new to veterinary medicine, it has been demonstrated to be an effective treatment in numerous animal models of disease such as osteoarthritis, tendon repair, fractures, muscular dystrophy, autoimmune problems, and other disorders.