However, if there is no free
trial number from your area you can STILL JOIN AXXESS and chat with local / regional Spanish singles.
Not exact matches
Plenty of other retailers,
from American Eagle to Safeway, have been testing iBeacons in
trial runs at a limited
number of stores, but until now, Apple, unsurprisingly, was the only company to put its full trust in the technology and roll it out across all of its stores.
In the last few years, the
number of clinical
trials in this field has exploded, along with the flurry of money
from Big Pharma and investors, stirring optimism in the fight against cancer.
Kirra Cheers, a photographer
from Brooklyn, recently set out to document her
trials and tribulations using Tinder, a wildly popular app that allows users to approve or deny potential mates based on a small
number of pictures and a short bio.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the
number of insured patients; the possibility of unfavorable results
from clinical
trials involving investigational compounds; Gilead's ability to initiate clinical
trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data
from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified
from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
«The church will become small and will have to start afresh more or less
from the beginning... As the
number of her adherents diminishes... she will lose many of her social privileges... It will be hard going for the Church, for the process of crystallisation and clarification will cost her much valuable energy... But when the
trial of this sifting is past, a great power will flow
from a more spiritualised and simplified Church... And so it seems certain to me that the Church is facing very hard times.
Of note, our point estimate for premature death exceeds the annual
number of U.S. deaths
from cervical cancer (3,909), asthma (3,361), or influenza (3,055).45 If a randomized control
trial were to demonstrate similar effects to those reported in the observational literature, the «
number needed to treat» with optimal breastfeeding to prevent a case of maternal hypertension would be 35, to prevent a maternal MI would be 135, and to prevent a case of breast cancer would be 385.
Research shows that families typically receive roughly half of the
number of home visits expected.16, 17 For example, across three randomized controlled
trials conducted of Nurse Family Partnership, average dosage of visits ranged
from 45 to 62 percent.18 Research also shows that many, perhaps most, families enrolled in home visiting programs drop out before their eligibility ends.16, 19,20 Some home visiting studies have varied the dosage that families were offered and found that fewer home visits produced outcomes similar to higher levels of exposure.21
In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie,
from clinical
trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a
number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled
trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.
With his name coming up each day in the
trial, Cuomo could feel backlash
from a
number of
trial revelations:
Observers will be watching to see how well he raises campaign cash, and also how he manages candidate recruitment — especially at a time when he has a
number of aging members and two — including his predecessor, Dean Skelos; and his deputy majority leader, Tom Libous; facing federal corruption
trials that could result in their abrupt ouster
from office.
Here are some more startling
numbers, according to the BBC: 6,000 military personnel arrested, including more than two dozen generals awaiting
trial; 9,000 police officers fired; almost 3,000 judges suspended; and more than 250 members of Prime Minister Binali Yildirim's staff removed
from their posts, as have 1,500 Finance Ministry employees.
The bill would make it mandatory for researchers to publish all information
from cancer clinical
trials, with the goal being to get more researchers to work together and bring down the
number of duplicative studies.
Former top gubernatorial aide Joe Percoco is seeking to have the federal case against a
number of current co-defendants severed
from his own upcoming criminal
trial, with his lawyer arguing that he had nothing to do with charges faced by six of them.
Peers
from the across the political spectrum (but notably many Liberal Democrats) voted for a
number of measures which guarded against the plans, including giving judges, not Ministers, the say over the use of the secret
trials.
Hearing those complaints, Gov. Andrew Cuomo proposed changes in his budget plan but they were rejected, having drawn criticism
from a
number of disparate but politically potent groups including unions,
trial lawyers and the state medical society.
DOWNTOWN BROOKLYN — President Trump's deportation policies have immigration officers swooping into courthouses, making arrests in record
numbers, and preventing legal citizens
from exercising their right to a fair
trial, according to allegations
from New York Attorney General Eric Schneiderman.
In the CSU study, Orme and his team found that BCG strongly inhibited a
number of virulent strains of TB obtained
from the clinical
trial site around Cape Town.
The HYPO - RT - PC
trial, a randomized multi-institutional phase III
trial in Scandinavia, was designed to assess outcomes
from highly accelerated extreme hypofractionation, which is delivered in smaller
number of high doses — seven fractions of 6.1 Gy each in this study.
The
number of newly registered NIH - funded
trials decreased 24 percent over the same period
from 1,376 in 2006 to 1,048 in 2014.
The three
trials planned as part of this initiative will recruit a total of 658 patients
from a
number of centres across the UK — with the scope to add more
trials in the future.
The
number of females in the 16 - hectare
trial plot was estimated
from the proportion of jam - jar - sized pots placed there in which A. aegypti eggs were found.
The
number of newly registered industry - sponsored
trials increased 43 percent over the time period
from 4,585 in 2006 to 6,550 in 2014.
«However, a
number of clinical
trials have suggested that both chemotherapy and radiotherapy are associated with the risk of suffering heart disease as a consequence of treatment,» says Hermann Brenner
from the German Cancer Research Center (DKFZ) in Heidelberg.
He pulled the
number of cases produced per acre — a yield metric important to processors that he calls «case production» —
from each
trial, and then incorporated environmental data to calculate yield stability for 12 of the most commonly planted hybrids grown for processing.
A statin drug commonly used to lower cholesterol is not effective in reducing the
number and severity of flare ups
from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical
trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..
Data
from the clinical
trial did show that the combination therapy substantially decreased the
number of pulmonary exacerbations and hospitalizations, while also beneficially increasing the weight of CF patients.
Although the average
number of sessions in his
trial was 24, the actual
number ranged
from two to «some real diehards doing it several hundred times,» he says, and he saw no difference in performance between the extremes.
A
number of new clinical
trials aim to take cells
from a patient, such as blood cells or immune cells, edit them and transfer them back with new power to undermine diseases like cancer or sickle cell anemia.
Fortunately, there are a
number of other positives that we can take
from the
trial as a whole.»
In an editorial accompanying the published article in Circulation, experts
from the Technische Universität and the Munich Heart Alliance, Gjin Ndrepepa and Adnan Kastrati, affirmed that, if confirmed by a subsequent analysis of large
numbers of patients, the results of METOCARD - CNIC
trial are likely to lead to a change in clinical practice: «In this regard, a pharmaco - protective strategy able to reduce infarct size by 20 percent when used in conjunction with primary PCI nurtures great hope in clinical benefit.»
The
numbers ScienceInsider heard ranged
from 50 % of a group that does nonprimate work and clinical
trials to just 10 % of one institute's entire intramural program.
By combining two or more of these outcomes to create a single category, you can say it helped «A and B» even if it only helped A and not B. For example, although there was no statistically significant effect
from tPA in the NINDS
trial on the
number of patients who died, there was a small decrease in disability for those who survived.
As part of a clinical
trial conducted at Northwestern University in Chicago, Illinois, Ildstad and colleagues extracted bone marrow - producing cells
from kidney donors and then removed cells likely to cause GVHD while expanding the
number of «facilitating cells» that make an organ recipient's system more receptive.
In a presentation of early clinical
trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists
from the University of New Mexico Comprehensive Cancer Center reported that a large
number of study participants responded well to the drug combination.
Randomized controlled
trials showed that zinc supplementation can reduce the severity of morbidity
from a
number of common childhood infections, including diarrhea, pneumonia, and possibly malaria, by one - third.
Many of these novel cancer immunotherapy approaches, which originated
from basic science research in CCIR laboratories, are now being explored as new treatment modalities in patients, with a significant
number advancing through clinical
trials towards FDA approval.
«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence
from preclinical studies and a
number of small clinical
trials.
The different arms of the
trial were very well - matched as regards age (average age ≈ 55 y, ± 5 - 7 y depending on subgroup), education, time
from onset of disease, and MDS - UPDRS scores at onset; the only evident differences were a higher
number of males and higher body weight in the low - dose treatment group.
Based on positive results produced
from a
number of scientific clinical
trials, coronary artery disease therapy using adult stem cells is a promising new method of treatment for coronary artery disease patients.
«As the only engineer in the U.S. Senate,» Sununu said, «I've been proud to protect funding for the National Science Foundation
from political manipulation and fully support funding for adult and amniotic stem cell research — which has already resulted in a
number of treatments that have proven to be successful in patient
trials.»
It aims to increase the
number of successful new treatments for cancer by taking undeveloped anti-cancer agents
from industry and putting them into clinical
trials.
Our physicians and scientists are working on a
number of initiatives, including collecting blood and bone marrow
from patients to better understand the causes of bone marrow failure syndromes and MDS; exploring possible genetic factors that guide medical care; collecting blood and bone marrow to identify specific proteins that are faulty and how these defects relate to clinical complications and outcomes; and clinical
trials to improve stem cell transplants for disorders such as dyskeratosis congenita.
In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived
from a
number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical
trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.
Most of the
trials applied a block design for fMRI data acquisition, with a time range for each block of 8 sec to 6 min, and the
number of blocks ranged
from one to 12 blocks.
A yearlong weight loss
trial found that a group of subjects consuming soup twice a day lost more weight than another group consuming the same
number of calories
from two snacks a day.
It would be more compelling to have data
from a
number of human
trials.
An FDA advisory committee will meet this week to review data
from clinical
trials of the experimental diabetes drug dapagliflozin, which have revealed an unusually high
number of users who developed bladder cancer or breast cancer.
Apart
from the obvious difficulties with doing randomized controlled
trials there is a
number of confounding factors (59,60).
Then,
from about 1985 to 2005, a great
number of clinical
trials were conducted on the theory that vitamin supplements prevent chronic degenerative diseases, like cancer.