Sentences with phrase «trial phases by»

At both firms, Ms. Chan successfully litigated cases in both pre-trial and trial phases by obtaining favorable outcomes and verdicts for their clients.

Not exact matches

Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.

It tells the story of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety of a drug under development by giving it to healthy subjects and examining any side effects they experience.

Michigan Attorney General Bill Schuette says his Flint water crisis investigation is shifting to the «the trial phase,» but before it gets there, he's ramped up the stakes by charging five state and local officials with manslaughter for their actions related to the Flint water crisis.

Instead, the huge Pathfindersystem that underpinned the Universal Credit trial phase was supplied by HP, Accenture, IBM and BT and ran into serious trouble at a cost of hundreds of millions of pounds.

Another method, if one goal was to smooth out sudden generational shifts, would be to appoint some larger pool of full Justices, not acting as subs, but as a full rotating roster, [something like one of those watches or clocks that shows phases of the moon], advancing by one justice per trial.)

«The number of cases in which people try to introduce neurotechnological evidence in the trial or sentencing phase has gone up by leaps and bounds,» says Joshua Sanes, director of the Center for Brain Science at Harvard University.

The Rolls Royces of science experiments — relatively low risk and decent payoff — are Phase I drug trials conducted by pharmaceutical companies.

Would you say that the phase I trial done by Acambis, based in Cambridge, U.K., and Cambridge, Mass., has been successful?

The drug was developed by Lawrence - based CritiTech, and the drug - testing and phase I clinical trial were conducted by KU Cancer Center researchers, led by Stephen Williamson, M.D., medical director of Cancer Clinical Trials.

These are the conclusions of the Phase I Clinical Trial, sponsored by the Spanish National Cancer Research Centre (CNIO) and carried out by CNIO ́s Breast Cancer Clinical Research Unit.

Results of the two - year phase 2 trial — conducted by a consortium led by investigators at Massachusetts General Hospital (MGH), Harvard School of Public Health, and the University of Rochester — are being published in JAMA Neurology.

The recent phase 2 STEP trial of the HIV vaccine (V520) showed disappointing results, but another vaccine made by GeoVax will be moving into phase 2 clinical trials in the next few months based on promising phase 1 results.

Success with these models led to a small phase I clinical trial in which an individual's good bacteria with antimicrobial activity was grown, formulated in a skin cream and applied once to the forearm of the eczema patient infected by S. aureus.

Promising results of an earlier, initial, multicenter clinical trial of nivolumab, first reported in 2013 and directed by Brahmer, led to the current phase III trial of 260 patients treated at hospitals across the world.

After phase III trials, reported in 2006, ended in disappointment for the prostate cancer vaccine Provenge (made by Dendreon in Seattle), subsequent analyses revealed that men whose prostate cancer had spread survived a median of 4.5 months longer than those given a placebo.

The company has already garnered a fair amount of attention and is funded by the US National Institutes of Health (NIH) in Bethesda, Maryland, to conduct a phase II clinical trial in people with pain conditions such as neuralgia, fibromyalgia or migraines.

The ZPIV vaccine candidate was developed by WRAIR as part of the US Department of Defense response to the 2015 - 2016 outbreak of Zika virus in the Americas, and it was advanced to a Phase 1 trial in November 2016.

Three studies presented at the American Epilepsy Society's 69th Annual Meeting in Philadelphia highlight emerging efficacy and safety data of Epidiolex, a pharmaceutical liquid formulation of cannabidiol, which is currently undergoing U.S. Food and Drug Administration (FDA) authorized Phase 3 pivotal clinical trials in the United States and across the globe by GW Pharmaceuticals.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011 preclinical results published by Pacifici and Iwamoto.

An affordable hepatitis C combination treatment including the new drug candidate ravidasvir has been shown to be safe and effective, with extremely high cure rates for patients, including hard - to - treat cases, according to interim results from the Phase II / III STORM - C - 1 trial presented by the non-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) at the International Liver Conference in Paris.

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

The plan is to predict very early which drugs are likely to succeed and which are not, and promote the winners rapidly to larger (phase III) trials, which most likely would be run by private companies, without data sharing.

The phase 2 randomized clinical trial was conducted by the Eastern Cooperative Oncology Group, enrolling 245 patients with stage 3 or stage 4 metastatic melanoma who had been treated with other drugs.

A phase I trial conducted by investigators at the Colorado State University Veterinary School in 30 dogs with non-Hodgkin's lymphoma with HCQ and the standard chemotherapy doxorubicin (DOX) showed a 100 percent clinical benefit rate.

A phase I clinical trial conducted by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.

The Phase 3 trial was funded by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), both part of the National Institutes of Health, and was conducted by the NIH - sponsored Clinical Islet Transplantation (CIT) Consortium.

The phase 1 / 2A trial, led by Dr. Amir Kashani, is being conducted at the University of Southern California Roski Eye Institute at the campus's Keck School of Medicine.

Yong, a neuroscientist, initially had the idea to test the acne medicine in an animal model since minocycline has many anti-inflammatory properties that he thought could be useful in treating MS. Soon after obtaining successful research results, in studies also supported by the MS Society of Canada and MSSRF, Yong teamed up with Metz who led the transition into a pilot clinical trial, then a Phase 2, and finally the definitive Phase 3 trial.

The team hopes to open a Phase I clinical trial at Lurie Children's by the end of 2017.

High - intensity exercise three times a week is safe for individuals with early - stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by Northwestern Medicine and University of Denver scientists.

Indeed, the authors note the speed with which a second FDA - approved drug believed to have promise in subduing HIV, Deferiprone, has moved directly from tests in culture to a phase I human trial conducted in South Africa, thanks to previously published results now reinforced by additional research in culture described in the current paper.

«The data from these two Phase III trials conducted in Europe and in the U.S. support the effectiveness of this novel photo - protective drug, offering the patients in Europe — where the drug has been approved by the European Medicines Agency — the opportunity to perform their daily functions without the pain induced by sun exposure,» said Robert J. Desnick, PhD, MD, Principal Investigator of the U.S. Trials and Dean for Genetic and Genomic Medicine, Icahn School of Medtrials conducted in Europe and in the U.S. support the effectiveness of this novel photo - protective drug, offering the patients in Europe — where the drug has been approved by the European Medicines Agency — the opportunity to perform their daily functions without the pain induced by sun exposure,» said Robert J. Desnick, PhD, MD, Principal Investigator of the U.S. Trials and Dean for Genetic and Genomic Medicine, Icahn School of MedTrials and Dean for Genetic and Genomic Medicine, Icahn School of Medicine.

Two Phase III trials, conducted in Europe and in the United States by researchers at the Icahn School of Medicine at Mount Sinai and six other U.S. sites, showed that the duration of pain - free time in the sun and quality of life were significantly improved by treatment with afamelanotide, a novel synthetic version of a melanocyte - stimulating hormone.

Afferent Pharmaceuticals today announced publication of results from a Phase 2 clinical trial demonstrating that the company's novel drug candidate, AF - 219, reduced daytime cough frequency by 75 % compared to placebo in patients with treatment - refractory chronic cough.

The study — conducted by the Clinical Investigator Collaborative, a multi-centre, Phase II clinical trials group supported by the Allergy, Genes and Environment Network (AllerGen)-- recruited 31 patients over five sites across Canada.

The Phase 2/3 trials will be sponsored by Vtesse, a new biotech company that was formed specifically to evaluate the safety and efficacy of cyclodextrin for the treatment of NPC and ultimately obtain FDA labeling if the drug is effective.

The researchers plan to carry out phase III randomized controlled clinical trials to determine the actual rate of effectiveness by comparing those treated with the ketogenic diet to a group tube - fed a normal, nonketogenic diet.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

In a few weeks, meeting participants learned, enough data may be available from small phase I trials of a vaccine jointly made by the U.S. National Institute of Allergy and Infectious Diseases and GlaxoSmithKline (GSK) that began in September to launch efficacy studies.

An Ebola vaccine made by GlaxoSmithKline (GSK) in Rixensart, Belgium, is the furthest along, having entered phase I human trials on 2 September.

Results from a phase III trial with another antibody that targets β amyloid — solanezumab, developed by Eli Lilly — should be announced later this year.

Based on these results, two phase 3 trials are being planned for platinum - sensitive and platinum - resistant ovarian cancer patients by one of NCI's new National Cancer Trial Network Groups, the NRG Oncology Group (formerly 3 cooperative groups: the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG).

A $ 2.4 million, 12 - week phase 1 trial testing the safety and tolerability of the steroid allopregnanolone for treatment of mild cognitive impairment and Alzheimer's, led by Roberta Brinton and Lon Schneider of the University of Southern California in Los Angeles.

This study is part of Phase one of the RECOVER Program, a multi-phase project, involving 10 intensive care units across Canada, co-led by Drs. Margaret Herridge, Scientist at the Toronto General Research Institute, and Cameron, in collaboration with the Canadian Critical Care Trials Group.

This investigator - initiated phase II trial, called TOPARP - A, was led by researchers at The Institute of Cancer Research, London and The Royal Marsden NHS Foundation Trust, and also involved several other institutions in the UK.

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

Although just published in The Lancet, those findings have since been overtaken by strikingly positive results from the larger phase III trials.

The Phase III clinical trial, conducted by the Radiation Therapy Oncology Group (RTOG), randomized 637 patients at multiple centers, including the University of Maryland Greenebaum Cancer Center, into two groups.