Sentences with phrase «trial using phase»

Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract

Not exact matches

The combo is being used in phase III clinical trials.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

Completing ed enrollment of its Phase 3 Resolve trial, which is testing its RSV F Vaccine use in adults age 60 and older.

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

Now that they've demonstrated the significance of insulin signaling in the human mammary gland, they are planning a phase I / II clinical trial with a drug used to control blood sugar in type 2 diabetes to determine whether it improves insulin action in the mammary gland, thus improving milk supply.

The team is optimistic about CGP3466B because it has already been shown to be nontoxic and nonaddictive in phase I clinical trials that explored its use for Lou Gehrig's and Parkinson's diseases — though it did not prove effective in treating those conditions.

In 1996, when RMP - 7 was first used on brain cancer patients in a Phase 1 clinical trial at UCLA, it was found to be safe, with virtually no side effects.

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

They have the opportunity to be exposed to a wide variety of clinical and patient - oriented research, from Phase I, II, and III trials to collection of samples and clinical data used to identify genetic variation that leads to human disease.

In phase 3 trials for adults with high - risk, secondary AML, there was a statistically significant improvement in overall survival compared to patients who received a regimen using chemotherapy drugs delivered in the standard way.

Researchers leading those trials are now training a cadre of therapists to deliver a form of psychotherapy tailored for use with MDMA, in preparation for the phase III trials.

Just a few weeks ago, WHO said that using any of the experimental drugs or vaccines in the pipeline simply wasn't in the cards, because none of them have been through a phase I clinical study, the type of trial in which medical products are tested on healthy volunteers to study their toxicity.

In the phase I clinical trial, Geron Corp. will use stem cells to treat spinal cord injury.

Watterson and his collaborators have a new National Institutes of Health (NIH) award to further refine the compound so it is metabolically stable and safe for use in humans and develop it to the point of starting a phase 1 clinical trial.

A pair of research teams, using very different techniques, are still building toward a trial phase — meaning we are still a few years away from seeing the promise of the Vacanti ear become reality.

Arizona: Voters approved Proposition 303, 78.3 % to 21.7 %, permitting terminally ill patients and their doctors to use experimental treatments that have completed only preliminary phase I safety and dose trials.

Furthermore, the safety profile was consistent with the safety outcomes of the double - blind phase and other trials using T - sol.»

But the new formulation hadn't been through phase I safety trials in humans and so couldn't be used in Ebola patients.

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

For what may be the first time, fMRI scans of brain activity have been used as evidence in the sentencing phase of a murder trial.

Notably, this is also the MOI being used in an adoptive therapy phase I clinical trial with R5 - ZFNs.

Adding the monoclonal antibody drug trastuzumab — already used to treat certain breast cancers — to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value.

The phase in the development of a new treatment where clinical trials are conducted using many patients, to determine whether the treatment is effective

In PNP's Phase I trial, an adenoviral vector is used to deliver E. coli PNP to head and neck tumors followed by intravenous administration of the prodrug fludarabine.

Phase III Randomized, Placebo - Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy + / - One Year of Everolimus in Patients with High - Risk, Hormone Receptor - Positive and HER2 / neu Negative Breast Cancer.

Dr. Xianmin Zeng is currently in discussions with the NIH (National Institutes of Health) Center for Regenerative Medicine and the NIH Clinic Center on using the cells for a Phase I clinical trial.

Under the agreement, Biotecnol and Cancer Research UK's Centre for Drug Development will collaborate to take forward Tb535H through a Biotecnol - sponsored first - in - man Phase I clinical trial, using Cancer Research UK's drug development expertise in return for shareholdings in Biotecnol.

This led the team to package the gene editing tool into AAV, used in late - phase clinical trials in the U.S. and also already approved in a gene therapy drug in the European Union.

GenIbet's core activity is the manufacture and supply of materials for use in early stage drug development, pre-clinical studies and cGMP manufacturing from Phase I to Phase III clinical trials.

Three additional Phase 1 trials using ZPIV are scheduled to begin this year:

Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.

The treatment, which involves using an AAV vector to deliver high activity variant of the Factor IX gene, is currently undergoing Phase I / IIa clinical trials.

Human embryonic stem cellsImage: Wikimedia commons, Nissim Benvenistylinkurl: Advanced Cell Technology; http://www.advancedcell.com/ (ACT) filed an Investigational New Drug (IND) application yesterday (November 18) to conduct a phase I / II trial using hESCs to treat a genetic eye disease.

-LSB-...] There are many ongoing clinical trials (Phases I, II, and III) using adipose derived MSC's to treat conditions as varied as COPD, pulmonary fibrosis, congestive heart failure, osteoarthritis, Parkinson's disease, diabetes, Autism, Crohn's disease, multiple sclerosis, macular degeneration, urinary incontinence, neurological disorders and many other conditions.

A humanized monoclonal antibody, now approved for use in metastatic melanoma, showed activity in a phase II trial with RCC.

But it was ultimately abandoned after a reformulated version used in the Phase II trial triggered meningoencephalitis in some 6 % of patients.

They initiated their Phase 1 BIIB054 trial in 2015, and reported promising early results of its use in an animal model of Parkinson's back in the summer of 2016, but have never published the results, issued press releases, or held conference calls to share their findings with the wider public.

Contrast this to the over 5,800 successful clinical trials using non-fetal stem cells to treat diseases that are already advancing to phase II and phase III trials.

The database was locked for the primary unblinded analysis after study day 90 so that results could be used to plan a Phase 2 trial, and the study continued in a single - blinded fashion, although individual study allocations were not disclosed to on - site study investigators or staff, with the exception of the principal investigator.

The L - arginine - induced pancreatitis is widely used as a relevant model for pre-clinical trials because 1) it is reproducible, 2) it shows dose and time dependent acinar cell necrosis, 3) it can be used for investigation of early as well as late phase of acute pancreatitis, and 4) it is suitable for investigation of extra-pancreatic organ damage (pulmonary, hepatic renal and circulatory) and insulo - acinar axis [3].

Additional information on the Phase 1 / 2a trial, including trial sites, can be found at www.clinicaltrials.gov, using Identifier NCT02302157, and at the SCiStar Study Website (www.SCiStar-study.com).

The new phase three study of the cervical cancer vaccine is needed for the FDA to consider approving it for more widespread use, said Ghamande, a principal investigator on the trial.

Several phase 1 and 2 trials have been carried out using nonselective ATP - competitive inhibitors such as imatinib to treat patients with advanced breast cancer.

Clinical Trials Research and Billing First in Human / Early Phase PET in Oncology Case - Based Dose Reduction in Pediatric Nuclear Medicine: Practical and Necessary Radioiodine Therapy for Hyperthyroidism: The State of the Art Spondylodiscitis: Role of Imaging for Diagnosis and Monitoring Treatment Response Current Status and Future Prospects: PET and SPECT Instrumentation Alternative Payment Models and Value - Based Health Care: Nuts and Bolts Maximal Tolerated Activity of Radioactive Iodine for Metastatic Thyroid Cancer Teaching Old Radiopharmaceuticals New Tricks Intraoperative Detection Devices and Probes Molecular Imaging of Lung Inflammation Standardization of Advanced PET / SPECT Data Acquisition and Analysis Thyroid Cancer Management: Novel Therapeutics and Management Options Targeting Radionuclide Therapy in Various Non-Malignant Arthritic Conditions Using Radiosynoviorthesis (RSO) Are You Prepared for a Radiation Accident?

«This Phase 1 trial in children with SMA Type 2 will allow us to evaluate safety, optimal dosing and proof - of - concept for efficacy of AVXS - 101 compared to the well - characterized natural history using the one - time intrathecal route of administration,» said Dr. Sukumar Nagendran, Chief Medical Officer of AveXis.

Despite the marginal improvements in survival of patients suffering from malignant glioma treated with gene therapy vectors, the clinical trials conducted so far using viral vectors, in particular adenoviral vectors, have proven that the use of adenoviral vectors is a safe therapeutic approach, even in large, multicenter, phase 3 clinical trials.

Phase 1 clinical trials are used in patients for whom conventional treatment has not worked, providing access to pivotal first - in - children, early - stage clinical trials with novel treatments before they are widely available.

2015 — Began a Phase 1b clinical trial of two experimental Ebola vaccines in Kampala, Uganda, using Chimpanzee Adenovirus type 3 vector (ChAd3) vaccines, co-developed by the VRC, National Institutes of Allergy and Infectious Diseases (NIAID) and GlaxoSmithKine.

However, sometimes the HVTN may use a special step called a phase 2b trial.