Sentences with phrase «trials of drugs»

Still, the study «certainly sets the stage for future clinical trials of drugs that show promise to (one day) improve the health of older adults.»

Rigorous experiments in animals have given way to clinical trials of drugs that target the HD gene in people, and there are more techniques for decreasing or eliminating huntingtin on the horizon.

Texas Children's Cancer Center is a member of the COG Phase I Consortium, a small and select group of institutions that administer Phase I clinical trials of drugs in early development.

Trials of drugs designed to reduce blood pressure in people with dementia have not been successful.

The next step, Srivastava said, is clinical trials of the drugs as a therapy for asthma and COPD — a process that should be expedited since aldose reductase inhibitors have already undergone Phase III clinical trials for diabetic neuropathy.

Preliminary trials of these drugs (for treatment of other forms of cancer) have shown that they have a good safety profile, which should accelerate testing in patients with glioblastoma.

In early clinical trials of these drugs, we noticed that in some breast cancer patients the tumors didn't just remain the same size — as would be expected with drugs that interfere with cell division — but began to recede, sometimes quite dramatically, said Goel.»

The problem was particularly obvious in trials of drugs to treat heart disease, which is the leading cause of death in women.

Industry representatives argue that the ethical and scientific procedures they currently use for human pesticide tests are no different from those employed in clinical trials of drugs.

Separate reports by other researchers on failed human trials of drugs that fought plaque would seem to corroborate this.

To understand how this pathway is implemented, in a recent study published in JAMA, researchers at Brigham and Women's Hospital and the London School of Economics and Political Science (LSE) examined the pre-approval and post-approval clinical trials of drugs granted FDA Accelerated Approval between 2009 and 2013.

Researchers evaluate the features of pre-approval and post-approval clinical trials of drugs granted accelerated approval by the FDA.»

But John Collinge of University College London, UK, and colleagues, who reported the clinical details of the most recent case, say people at high risk of vCJD should be informed, so they can be enrolled in clinical trials of drugs which are hoped to delay or prevent the onset of the disease.

Last month's presentation also got attention for what it didn't describe — trials of drugs that replace missing or deficient proteins to treat chronic diseases.

In a paper accepted for publication in the journal Pain, researchers at McGill University in Montreal analyzed the results of 84 clinical trials of drugs conducted around the world from 1990 to 2013.

Thomas says there are already human trials of drugs that seem to do that.

The committee suggest this is part of a bigger problem whereby clinical trials of all drugs with negative results are twice as likely to be withheld from the public as those with positive results.

Unfortunately for the firm, this enrollment halt may also implicate a future failure in a later - stage trial of the drug, PEGPH20.

A report by drug policy think tank Volteface stated that 3,700 people died from things like infected syringes and accidental overdoses and recommended a trial of drug consumption rooms to provide a safe, clean and legal space for users.

In 2002, Home Secretary David Blunkett announced that he might permit the medical use of cannabis if clinical trials of the drug were successful.

Alzheimer's is a disease for which there are still no treatments that fundamentally alter the course of the disease, as trial after trial of drug candidates have ended in failure.

Helicon completed a larger human trial of the drug to test for safety in 2008 (results are not yet available) and plans another trial this year.

Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.

In general, the researchers found liraglutide 3 mg to have a safety profile that was similar to that found in previous clinical trials of the drug in individuals with Type 2 diabetes treated with lower doses.

Because not all the trials of the drug have been published, she says, there are «serious doubts» about the drug's effectiveness.

For example, in 2006, six people enrolled in a UK trial of the drug TGN1412 were hospitalised after developing multiple organ failure.

The first clinical trial of a drug intended to delay the onset of symptoms of Huntington disease (HD) reveals that high - dose treatment with the nutritional supplement creatine was safe and well tolerated by most study participants.

The FDA had halted early clinical trials of the drug on 3 July, but said on 7 August that the drug could potentially be given to infected patients.

«That would be a great result if it was seen in a normal clinical trial of a drug.»

Davis hoped life might improve when he was chosen in 2012 to participate in a clinical trial of a drug called ocrelizumab.

Shurin cautions that at least two years of development will be needed before the first human trials of any drug.

«Our work included samples from a placebo - controlled trial of drugs against these parasitic worms.

Confidence in biotechnology companies was jolted last week by the news that a major clinical trial of a drug to combat severe blood poisoning had been halted.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

«It's the first clinical trial of a drug with this action in patients with cancer,» says Peter Lewis, the director of research and development.

Kipnes is currently recruiting patients for a second safety trial as well as a larger Phase 2 trial of the drug's effectiveness.

Physicians immediately began recruiting hundreds of people for a clinical trial of the drug, and that study is ongoing.

In collaboration with Vertex, HUB has tested ivacaftor on organoids grown from CF patients who had taken part in a clinical trial of that drug.

The researchers are now running a larger, double - blind, randomized clinical trial of the drug in 152 patients, planning to evaluate its effectiveness next October.

In this instance, they mentioned the collapse of TeGenero Ag's fateful small - scale trial of its drug TGN1412.

At a meeting last week of the International Society for Biological Therapy of Cancer in San Diego, California, Oncolytics Biotech of Calgary in Alberta, Canada, reported positive results from two trials of its drug Reolysin, which contains reovirus.

«There are a lot of questions about how to implement it,» says Connie Celum, an HIV researcher at the University of Washington in Seattle, who led a large trial of the drug in East Africa and has begun studies to answer practical delivery questions, such as which subsets of people are at highest risk.

Well - designed, placebo - controlled trials of the drug in men who do not meet the standard criteria for treatment have been scant in number, and their results have been inconsistent.

But a trial of a drug that does this, carried out 24 years ago, suggests it's worth investigating.

One case is a clinical trial of the drug Zidovudine, a medication that was 75 percent effective in preventing HIV positive mothers from transmitting the disease to their unborn children.

Healthy women in the US and Canada are soon to begin a trial of the drug tamoxifen to see whether it prevents breast cancer.

The Pulmonary - Allergy Drugs Advisory Committee of the FDA evaluated the results of a clinical trial of the drug Pulmozyme on 968 patients.

Nir Barzilai is planning the first clinical trial of a drug that could slow the body's deterioration

The first clinical trials of drug treatments are already under way.

And not only are they now not dying, you are essentially on the path to a true cure of a degenerative [neurological] disease, which is unheard of,» says Jeffrey Rothstein, a neurologist at the Johns Hopkins School of Medicine in Baltimore, Maryland, who was not affiliated with the trials of the drug and is not connected with either of the two companies involved in its development: Ionis of Carlsbad, California, and Biogen of Cambridge, Massachusetts.