Sentences with phrase «trials on rodents»

The vaccine, which has proven effective in trials on rodents and monkeys, works by mimicking the unique structure of the heroin molecule and its key metabolite, 6 - acetylmorphine.

Not exact matches

Sharpe highlights several hurdles on the route to a human equivalent of the drug, such as creating an oral version rather than the injectable form used in the rodent trials.

Subsequent to this, weight - loss trials within human populations 35 - 52 as well as some rodent trials 22, 27, 53, 54 have used an array of IER protocols which permit a small energy load to be consumed on the «fast» day, so that energy intake is partially but not completely restricted.

Most rodent trials 12 - 30 and preliminary trials in non-obese humans 31 - 34 have used total IER protocols in which energy intake is completely restricted on alternate days.

Rodent Models: A growing number of trials have examined the effects of IER (100 % ER / alternate days) on cardiovascular risk factors in rodent mRodent Models: A growing number of trials have examined the effects of IER (100 % ER / alternate days) on cardiovascular risk factors in rodent mrodent models.

It will also be important to determine the effects of IER in other populations, for example in individuals with more profound metabolic derangements such as those with established T2DM, the evidence for which is relatively sparse.36 Additionally, given that several rodent and human IER (50 - 100 % ER on restricted days) trials have demonstrated metabolic improvements in the absence of overall ER 15, 22, 27, 31, 53,105, one can speculate that IER may have potential applications within non-overweight populations and as a maintenance strategy post-weight-loss.

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

To date, with their support, we've completed a variety of activities to accomplish this goal, including environmental toxicological monitoring on islands where rodent removal has been achieved, and conducting field trials to inform, design, and implement appropriate management strategies to reduce risk to non-target wildlife species during invasive species removal.

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16