Epigenetics: The Ultimate Mystery of Inheritance By Richard C. Francis (W. W. Norton) Researchers once considered DNA to be the exclusive carrier of heredity, but recently they have discovered that certain life experiences — smoking before puberty, say, or a high - stress pregnancy — can
trigger cellular changes that get passed along to future generations.
Not exact matches
What's more, the important part of this research is that one type of fat can
change to another, and that cold
triggers cellular mechanisms that lead to the formation of more brown fat.
HIF - 1 senses reduced oxygen levels and
triggers many
changes in
cellular function, including a
changed metabolism and sending signals for the formation of new blood vessels.
The misfolded prions can
trigger a domino effect by causing folding
changes in their normal
cellular counterparts, which turns them into toxic prions as well.
The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to
change — in particular the MAPK and PI3K
cellular pathways,
triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).
A critical next step for this work is to understand how senescent
changes in late life
trigger such destructive waves of
cellular necrosis.
The transcriptional
changes detected above may partially be related to
changes in the
cellular composition of blood
triggered by death.
Molecules in the extracellular environment bind specifically to cell - surface receptors and
trigger intracellular signaling, eventually leading to
changes in
cellular physiology.