Sentences with phrase «triggering apoptosis»

It can also kill many different types of cancer cells by triggering apoptosis (programmed cell death) without affecting normal cells.

[10] Methyl jasmonate, a plant stress hormone produced by many plants including rosemary, olive, and ginger, inhibits HK, triggering apoptosis in cancer cells.

Fortunately, experiments done by Dr. Jan Vijg at the Albert Einstein College of Medicine and others on mutations (changes in base sequence in DNA) and additional studies commissioned by SENS Research Foundation on epimutations (changes in the arrangement of methyl groups) suggest that these latter kinds of alterations - the kind that accumulate in cells without triggering apoptosis or senescence or contributing to cancer - accumulate too slowly to make a difference with the current lifespan.

In many cancers, p53 is prevented from triggering apoptosis by its attachment to BCL - xL.

In her experiment, Wang starved cultured rat muscle cells in order to trigger apoptosis, a genetic program that instructs cells to self - destruct.

They found that the therapy releases and / or activates the pro-apoptotic proteins Bim, Bak and Bax, which help trigger apoptosis.

In the current issue of Nature Medicine, John Pezzuto of the University of Illinois at Chicago and his colleagues report that a compound called betulinic acid triggers apoptosis or programmed cell death, in cultured melanoma cells.

By invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the cell.

Drugs are currently being tested that bind to BCL - xL to free BH3 proteins to trigger apoptosis.

When this machinery detects irreparable damage to the cell, p53 is unleashed to trigger apoptosis.

The tumor suppressor p53 is critical in the protection of cells against radiation - induced carcinogenesis, most likely through its ability to trigger apoptosis of radiation - damaged cells (45).

Phenethyl Isothiocyanate Triggers Apoptosis in Jurkat Cells Made Resistant by the Overexpression of Bcl - 2

Conversely, they have found that interfering with survivin expression in tumor cells is sufficient to trigger apoptosis, to enhance the efficacy of conventional anti-tumor treatment, and to exert potent anti-tumor activity in vivo.

Topotecan works by trapping Top1ccs in tumor cells, resulting in the DNA damage that triggers apoptosis.

Since TNFα is such a potent inducer of apoptosis through TNFR1 death domain signaling, and amiodarone treatment results in the down regulation of TNFα with concomitant upregulation in TNFR2 signaling in NSC alone, it is possible that amiodarone selectively kills NSCs by lowering the threshold of TNFα required to trigger apoptosis in NSCs via upregulation of TNFR2 pathways in NSCs and not dopaminergic neurons.

Apparently, most (epi) mutations in the cell are recognized as critical and trigger the apoptosis program, or make the cell senescent - and the rest, unfortunately, do contribute to cancer.

Additional work, however, revealed that in collaboration with TNFR1, TNFα can act upon TNFR2 through a ligand passing mechanism and trigger apoptosis [40].

Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered apoptosis in colon cancer cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer cells.

And, anthocyanins also trigger apoptosis — or cell suicide — in several different types of cancer cells.

The superoxide anions triggered apoptosis, the death of human skin cells.

This leads to β - cell damage, in part mediated by oxidant damage, that triggers apoptosis or programmed cell death.

Not exact matches

But in the following hours and days, the body's self - defense mechanisms backfire: White blood cells come in to clean up dead tissue, which causes massive inflammation, which in turn triggers healthy cells in the surrounding tissue to self - destruct in a process called apoptosis.

In a study published in 2006, he and other Johns Hopkins researchers tested two compounds similar to CGP3466B to see if they would block GAPDH from triggering cell death under the types of highly stressful conditions that would normally cause apoptosis.

This process, called apoptosis, is triggered in oocytes by the protein p63.

Once a woman sails past her mid-thirties, her eggs increasingly succumb to apoptosis, or internally triggered cell death.

Now, Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self - destruction of «injured» nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3 ′ Uridylated Intermediates Degraded by DIS3L2.

Fenofibrate - induced nuclear translocation of FoxO3A triggers Bim - mediated apoptosis in glioblastoma cells in vitro.

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

NK cells kill infected cells by releasing small cytoplasmic granules that trigger cell death (apoptosis).

Activation of ERK1 / 2 triggers G2 checkpoint which is considered protective from radiation - induced cell death [8, 9], while activated AKT is known to promote DNA repair and inhibition of apoptosis induction [10].

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

This is extremely problematic, as melatonin inhibits the proliferation of a wide range of cancer cell types, as well as triggers cancer cell apoptosis (self - destruction).

Specifically, researchers found that diets high in fiber trigger microorganisms in the gut to produce short chain fatty acids (SCFAs), which induce neutrophil apoptosis and the resolution of inflammation.

In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or osteoblastic differentiation.

In addition to helping you fall asleep and bestowing a feeling of overall comfort and well being, melatonin has proven to have an impressive array of anti-cancer benefits.4 Melatonin inhibits the proliferation of a wide range of cancer cell types, as well as triggering cancer cell apoptosis (self destruction).

Studies have shown gamma - tocotrienol selectively targets cancer cells, triggering cellular senescence and promoting apoptosis — a type of programmed cell suicide.