It has also been suggested that methylation is not the initial event in
triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).
Not exact matches
RNA interference (RNAi) is a phylogenetically widespread
gene -
silencing process
triggered by double - stranded RNA.
A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor
genes are
silenced — occurs in adult brains and can be
triggered by environmental cues.
One study revealed that
gene silencing triggered by mild heat stress continued in future generations of these worms, even after the initial heat stress was gone.
This form of
gene silencing is
triggered by a short piece of double - stranded RNA (the chemical cousin to DNA) that matches the
gene.