Sentences with phrase «triggers immune cell response»

«Vaccine used to treat cervical precancers triggers immune cell response.»

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And using cells from someone other than the cancer patient being treated might trigger an immune response against the foreign cells.

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

«We also showed that, once the NOD2 pathway trigger is initiated, the cells need a second, amplifying step to complete a full - strength immune response.»

«Similarly, triggering extra production of particular dendritic cells could improve the immune response to infections or vaccines.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

The experiments indicated that when dectin - 1 recognizes tropomyosin in house dust mites, shrimp or other common allergy - triggering species it suppresses airway cells» production of an immune molecule, IL - 33, which otherwise would promote an allergic response by immune cells.

In GVHD, donor cells trigger an immune response that attacks normal tissues, leading to a chain reaction of cellular and molecular responses that increase morbidity and mortality in these patients.

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatCell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatcell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

Antril, which is classified as an interleukin - 1 receptor antagonist, occupies the site on cells lining blood vessels where interleukin - 1 docks before it triggers an immune response.

The central idea is to encode an antigen as RNA and inject that into the skin of the patient, whose own cells then produce the protein that triggers an immune response, either to kill tumor cells or to prevent an infection.

Previous studies in mice have shown, however, that even genetically identical iPS cells can trigger an immune response after transplantation.

Now, scientists have modified Salmonella bacteria to trigger a particularly powerful immune response against human cancer cells implanted in mice, shrinking the tumors and — for the first time — preventing them from metastasizing.

The 3 - D scaffold effectively recruits and activates the dendritic cells to trigger an immune response against specific cells, such as cancerous cells.

In a report to be published in the journal Cell Host & Microbe online June 11, researchers showed that immune - system - triggering TB proteins, or antigens, were able to prompt a larger, prolonged immune system response just by being transported from infected dendritic cells to uninfected ones.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.

IFN - I triggers many different immune responses, but can also speed up the replacement of epithelial cells.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

«We now have the first marker for the capacity of brain immune cells to remove toxic materials,» says Haass, «and its increase long before full Alzheimer's dementia shows that there is early neuronal injury that does not yet affect memory, but already triggers a microglia response.»

Antigens are flags on the surface of cells, and they trigger the immune response when the flags are foreign.

Receptors on T - cells recognize antigens, or pieces of other cells that trigger an immune response, particularly antibodies.

The immune response triggered by eczema could help prevent tumour formation by shedding potentially cancerous cells from the skin.

The same autoimmune response that triggered the disease would likely attack new β cells derived from the patient's own iPS cells, and a normal immune response would destroy ES - derived β cells, which would appear foreign.

Retinal cell death can be induced by phagocytic immune cells that infiltrate the tissue in response to injury or infection, but the molecular signals that trigger phagocyte invasion are largely unknown.

The vaccine is unique to the individual participant and is engineered to trigger an immune system response to kill tumor cells that may remain following surgery.

The immune response triggered by fetal cells might help the body detect cancer cells later in life.

In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships to investigate innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell responses against viruses or tumors.

Peng Zhou at the Wuhan Institution of Virology in China and his colleagues triggered immune responses in the white blood cells of mice and Chinese rufous horseshoe bats, which harboured the SARS virus.

To trigger a vigorous immune response, antigen - presenting cells (APCs) put on display chopped - up peptides from pathogens or tumor cells.

Minguet and her team have discovered that the protein Caveolin - 1 regulates this organization, making it the key to activation of the B cells and the triggering of an immune response.

Wu's team killed the stem cells with radiation so they wouldn't keep growing and combined them with a substance that helps trigger an immune response.

Gene therapy, which often employs viruses to deliver the good genes to a body's target cells, has been known to trigger severe immune responses and was blamed for the death of an 18 - year - old in 1999, who was receiving gene therapy for a hereditary metabolic disorder.

Rather, he was intrigued by its documented ability to dampen the immune responses triggered by vaginal epithelial cells when exposed to toxins.

There, the immune cells interact with liver cells and trigger an inflammatory response that damages the liver tissue and also destabilizes the metabolic activity of the liver cells.

In the new paper, researchers led by Dr. Torres showed that LPA keeps T cells inactivated even after they have «seen» a target, or antigen, on a cancer cell that would normally trigger an immune response.

The saliva triggers an immune response in which white blood cells called neutrophils and myeloid cells rush to the site.

Most importantly, many of the T cells were able to recognize the tumor cells directly, demonstrating that the vaccine had triggered a tumor - specific immune response that could target the patient's tumor.

On a cellular level, FnEDA triggered an immune response in skin cells, leading to fibrosis.

The cornea and its stromal stem cells themselves appear to be «immune privileged,» meaning they don't trigger a significant immune response even when transplanted across species, as in the Pitt experiments.

While the understanding of dendritic cell function is expanding, it is already evident that they have the ability to turn on or turn off areas of the immune system, thus either triggering or silencing a response.

A study published by Cell Press November 21st in the journal Immunity reveals how HIV - 1 escapes detection by essentially becoming invisible to a patient's immune system, whereas HIV - 2 triggers protective immune responses in patients.

Humans with FHL2 may not have a truly naive immune response to their viral trigger, as they could possess a pre-existing memory T cell response to an HLH trigger without prior exposure to this specific trigger.

Some not - yet - identified molecule, or combination of molecules, such as proteins, fats, or sugars, made by bacteria cause the immune system to produce T helper 17 cells (Th17), which trigger a surge in inflammation as part of the response to a pathogenic strain.

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

A new UC San Francisco study has shown that a cancer - killing («oncolytic») virus currently in clinical trials may function as a cancer vaccine — in addition to killing some cancer cells directly, the virus alerts the immune system to the presence of a tumor, triggering a powerful, widespread immune response that kills cancer cells far outside the virus - infected region.

While ZVex primes the immune system by triggering the generation of CTLs, GLAAS, by activation of CD4 cells, boosts the immune response by expanding and enhancing the function of CTLS and other anti-tumor mechanisms.

As fibrin builds up in the brain, it triggers an immune response that leads to the degradation of the nerve cells» myelin sheath, over time contributing to the progression of MS.

This is often enough to halt the infection but the second part of the immune response is adaptive immunity, when dendritic cells activate T lymphocytes and trigger a cascade of immune reactions, such as the formation of antibodies and killer cells that clear the infection from the body and form a memory of the invading pathogen.