Sentences with word «trk»

Loxo filed for accelerated FDA approval based on three studies, totaling 55 patients with TRK fusions.

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The investigators conducted three clinical studies of larotrectinib in patients with TRK fusion — positive cancers: a phase I adult study, a phase I / II study of children, and a phase II study including adolescents and adults.

The much - awaited Benelli TRK 502 is expected to launch in India in 2018.

Early - phase data on larotrectinib validate TRK fusions as therapeutic targets and show they lead to tumor - agnostic sensitivity to this agent.

Wrote the paper: TS AB NBV TRK.

A Modified Chinese Herbal Decoction (Kai - Xin - San) Promotes NGF - Induced Neuronal Differentiation in PC12 Cells via Up - Regulating Trk A Signaling.

A Phase II Basket Study of the Oral TRK Inhibitor LOXO - 101 in Subjects with NTRK Fusion - Positive Tumors

«Screening strategies that include assays with the ability to detect TRK fusions will be needed in order to identify patients who may benefit from larotrectinib.»

The median time to response was 1.8 months, and responses occurred regardless of tumor type, patient age, or specific TRK fusion characteristics.

Recurrent chromosomal fusions involving TRK have been found in a diverse group of cancers in both children and adults.

Brzo trk po naocale, jer ako vas moj...

Preferably, I would like to drive in Al., FL, GA., for my next trk job.

I am a 47 yr old divorced man w / 3 kids all grown drive trk for a living am a caring man w / a good sense of humor looking for a long term relationship with a good caring woman...

Trk Dating ONEDATE.

ON - TRK indicates the student is on - track for performance at grade level.

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The most recent occasion for this conundrum to be grappled with was in TRK and another v ICM [2016] EWHC 2810 (QB).

EVENT COORDINATING ASSISTANT, 06/2014 to 10/2014 LIBRARY — San Antonio... trk = pub - pbmap Professional Summary Focused Library Assistant effective at prioritizing tasks,... Internship, 06/2015 to 08/2015 John Peace Library — San Antonio, Texas, United States

Analyzed the data: TS TRK.

The Benelli TRK 502 is gets a promising design language with appreciable power output and boasts of a competitive price tag thanks to local assembly.

According to combined results from the two trials, the investigational anticancer therapeutic entrectinib — which targets a family of proteins called TrkA / B / C, ROS1, and ALK — was safe and tolerable and showed signs of clinical activity in patients who had several different types of cancer with NTRK1 / 2/3, ROS1, or ALK gene alterations and who had not previously been treated with Trk -, ROS1 -, or ALK - directed targeted therapeutics.

«Our data not only validate TRK fusions as therapeutic targets but also show that they lead to tumor - agnostic sensitivity to larotrectinib,» the authors wrote.

Conceived and designed the experiments: NBV TRK.

Known as Slit and Trk - like family member 1 (SLITRK1), it was related to a group of genes known to be involved in neuronal growth, guidance, and branching.

The drug, called larotrectinib, targets rare faults in a molecule called tropomyosin receptor kinase (TRK).

Larotrectinib, a highly selective inhibitor of all three tropomyosin receptor kinase (TRK) proteins, was recently shown to have marked and sustained antitumor activity in patients with TRK fusion — positive cancers, according to an analysis of three phase I and II cohorts.

Larotrectinib (LOXO - 101) and LOXO - 195 target tropomyosin receptor kinase (TRK) fusion proteins, which are a product of genetic alterations that occur across a range of different tumors.

The TRK 502 is expected to come with a 20 - litre fuel tank and the body will weigh over 200 kg.

The TRK 502 will also feature 320 mm dual front discs with a 260 mm single disc in the rear.

Power on the Benelli TRK 502 comes from a 499.6 cc twin - cylinder motor (same as Leoncino) tuned for 47.6 HP of power and 45 Nm of torque, paired to a 6 - speed gearbox.

Spare Tire Civic Type R comes standard with a lightweight and compact tire repair kit (TRK).

Hybrid models use a Tire Repair Kit (TRK).

To maximize trunk volume, the both models also feature an easy - to - use tire repair kit (TRK).

He's recently written up the value proposition for International Speedway Corporation (NASDAQ: ISCA), Speedway Motorsports (TRK), and Dover Motorsports (NYSE: DVD).

However, you can own it indirectly through International Speedway Corporation (ISCA), Speedway Motorsports (TRK), or Dover Motorsports (DVD).

This year, TRK was honored to help fospice cat Eddie find a home.

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Trinity Rescue Kit or TRK is a free live Linux distribution that aims specifically at recovery and repair operations on Windows machines, but is equally usable for Linux recovery issues.