Bona fide
trophoblast stem cell lines and extra-embryonic endoderm stem cells can be directly derived from expanded potential stem cells in vitro.
It is to these cells that Zernicka - Goetz attributes her success, as she believes
the trophoblast stem cells communicate with the embryonic stem cells and help them evolve.
Within this elementary biological structure, three types of cells begin to cluster and develop: the embryonic stem cells (which eventually become the body of the embryo), and two extra-embryonic types of cells -
the trophoblast stem cells (which develop into the placenta) and the endoderm stem cells (which go on to form the yolk sac).
While embryonic stem cells are widely studied, a lesser known, but still significant, population of stem cells also resides within the early developing embryo:
trophoblast stem cells (TSCs).
For the first time,
trophoblast stem cells have been isolated and cultured by researchers in Japan.
Figure 1: The blastocyst is a hollow sphere made of approximately 150 cells and contains three distinct areas: the trophoblast, which is the surrounding outer layer that contains
the trophoblast stem cells and later becomes the placenta, the blastocoel, which is a fluid - filled cavity within the blastocyst, and the inner cell mass, also known as the embryoblast, which can become the embryo proper, or fetus, and is where human embryonic stem cells are isolated from.
When the late blastocyst is implanted in the uterine wall, at day 7 or 8 in human development,
the trophoblast stem cells (in the trophoblast) quickly differentiate to form cells required for a firm implantation and, later, for the placenta.
Not exact matches
The blastocyst contains both embryonic
stem cells and
trophoblast cells.
Thus the only difference between totipotent and pluripotent cells is that totipotent cells divide and differentiate into both embryonic
stem cells and
trophoblast cells.
The NIH defines totipotent cells as the source of both embryonic
stem cells and of
trophoblast cells which give rise to extra-embryonic tissues such as the placenta.
What she has shown is you can make mouse embryonic
stem cells convert unidirectionally to
trophoblasts by activating a single gene.