«The additional information we can now derive from
tumor biomarkers such as E-cadherin, nm23 and microvessel counts should begin to allow us to tailor therapy according to individual tumor types,» added Samuel Hellman, MD, A.N. Pritzker Distinguished Service Professor of radiation and cellular oncology at the University of Chicago and co-author of the paper.
Unfortunately, the high background of normal proteins, along with the presence of circulating phosphatases and other degradation enzymes, consistently stump researchers searching for these
rare tumor biomarkers.
«Another important point is that targeted drugs in and of themselves are often quite useless if not combined with a patient's
individual tumor biomarkers to determine whether they are likely to benefit from a particular therapy.»
Tumor tissues of six patients were stained for two
different tumor biomarkers (CA IX and Topo - I) before and after treatment with CRLX101.
«We are eager to immediately enhance patient outcomes by incorporating candidate and novel
predictive tumor biomarkers into therapeutic decision making, making treatment rational and realistic,» Pishvaian says.
The clinical biostatistics team has strong connection with the Biometry department (Head A. Savignoni), the early phase clinical trial and precision medicine unit where patients are treated with drugs in development (Head C. Le Tourneau), the translational research department in particular the
Circulating Tumor Biomarkers laboratory (Charlotte Proudhon), and of course the other teams of the U900.
Diet - induced changes in tumor growth occur in parallel with changes
in tumor biomarkers such as proliferation and apoptosis which are associated with improved clinical outcomes in humans.
Furthermore, the expression of Id4 may serve as
a tumor biomarker that can predict the degree of tumor infiltration.»