Sentences with phrase «tumor blood vessels»
He previously revealed the existence of spontaneous immune responses in ovarian tumors as well as described how regulatory T cells and tumor blood vessels affect these responses.
cancerresearch.org
An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
They inhibit tumor blood vessel formation (angiogenesis) and tumor cell migration (needed for metastasis).
When the researchers examined the tumors, they discovered that the second drug acted by making the immune system hyper - alert to tumor proteins released by the viral infection, rather than through effects on tumor blood vessels.
«Our preclinical study indicates that SapC - DOPS does both and inhibits the growth of new tumor blood vessels, suggesting that this agent could one day be an important treatment for glioblastoma and other solid tumors.»
In addition, tumor blood vessel normalization also increases the barrier function of the blood vessels, which reduces the access of cancer cells to the circulation — the most important transport system for the spreading of cancer cells to other tissues.
Therapies that prevent tumor blood vessel growth are often used in clinics to fight cancer — but they are only effective in a particular subset of patients.
«Vaccine directed against tumor blood vessels suppress tumor growth, metastasis.»
In studies of cancer cells and of tumors in mice, vitamin D has been found to have several activities that might slow or prevent the development of cancer, including promoting cellular differentiation, decreasing cancer cell growth, stimulating cell death (apoptosis), and reducing tumor blood vessel formation (angiogenesis)(3 - 6).
Disappointingly, the results of these experiments have shown that the most abundant antibody fragment that we isolated from our library does not appear to affect the interaction of VEGF with its receptor suggesting that this clone would not inhibit the biological effects of VEGF on tumor blood vessels.
A preclinical study shows that an experimental nanotechnology drug called SapC - DOPS crosses the tumor blood - brain barrier, targets brain - tumor cells and retards growth of tumor blood vessels.
He envisioned a bigger «balloon» that would burst and release drugs to shut off tumor blood vessels — then a smaller balloon would release chemotherapy drugs.
The ability to enhance nanoparticle uptake is dependent on the level of expression of a molecule, called NRP - 1, to allow the peptide to bind to the tumor blood vessels.
«Tumor blood vessels are different than regular blood vessels,» said Sushanta.
But tumor blood vessels are built poorly and do a terrible job of carrying blood and oxygen — and drugs.
«We've discovered that when anti-angiogenesis drugs are used to lower the level of VEGF within a tumor, it's not so much a reduction in the endothelial cells and losing blood vessels as it is an activation of the tumor blood vessels supporting cells,» said Cheresh.