Sentences with phrase «tumor cell characteristics»
«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.
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«If we can identify the point at which tumor cells acquire the characteristics of stem cells, it will be possible to look for ways to interrupt the process and avoid progression of the disease.»
The cells in such a brain tumor can display very different characteristics, such as varying cell size or number of cell nuclei.
On the fly, neurosurgeons can use the pen - sized instrument on the brain to view the tumor cells with unique fluorescent characteristics that outline the tumor cells.
Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.
«Some cells that we call cancer stem cells adopt deadly characteristics where they can travel through the bloodstream to other tissue and form new tumors.
Which pathway the cell follows, and which genes are involved then largely determine the characteristics of a pancreatic tumor.
«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.
This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.
In this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cells.
This indicated that the cell of origin also has a direct influence on the characteristics of human tumors,» says Uhrbom.
«We discovered that several important characteristics of the cancer cells could be linked to the tumor's cell of origin.
Different cell types exhibit characteristic patterns of DNA methylation which enable scientists to draw conclusions about a tumor's cellular origin.
Lloyd A. Greene and Arthur S. Tischler of the Harvard Medical School demonstrated in 1977 that cells of the line designated PC12 (which are derived from a rat tumor) respond to NGF by acquiring properties characteristic of sympathetic neurons.
Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.
Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.
Bone marrow - derived mesenchymal stem cells undergo JCV T - antigen mediated transformation and generate tumors with neuroectodermal characteristics.
«But we know that tumors generally develop from a single cell or a small number of cells of a specific cell type, which is one of the major determinants of the characteristics of tumor cells,» explains postdoctoral researcher and co-author Dinorah Friedmann - Morvinski.
More recently, scientists including Benjamin Spike, a co-first author on the current work and post-doctoral fellow in the Wahl lab, have discovered that tumors often contain cells with stem cell characteristics revealed by their genetic signatures.
Known as tumor - initiating cells with stem like properties these cells have many characteristics in common with normal stem cells in that they are self - replicating and capable of giving rise to populations of differentiated cells.
«They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice,» says Friedmann - Morvinski.
«Cells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed SteCells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stecells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stewart.
Our underlying premise is that the tumor microenvironment is immune suppressive because cancer cells elicit responses characteristic of wound healing and tissue regeneration.
CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.
Co-engrafting mice with human tumors that retain the same characteristics and human immune cells, is a new platform to study the relationship between the human immune system and tumors and develop immuno - oncology - based cancer therapies.
CSCs are a minority group of cells (usually about 1 in 10000) within solid tumors of hematological cancers, which possess similar characteristics to normal stem cells.
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