To avoid the risk of tumor seeding (spillage of
tumor cell clusters and their subsequent growth at a site adjacent to the original tumor) through cystosyntesis (a procedure in which needle is inserted into the urinary bladder of an animal through the abdomen and a sample of urine is removed), urine may be collected by free catch or catheterization.
The work also reinforces the importance of finding
tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.
«Circulating
tumor cell clusters more likely to cause metastasis than single cells.»
Not exact matches
The «
tumors» are really
clusters of immune
cells that have invaded sites to kill cancer, he says.
Still, how melanoma
cells join into
tumors — whether by individual
cells coming together or small or large
clusters of
cells doing so — follows the same pattern as breast tissue cancer
cells: Cables are extended to reel in other
cells or
clusters.
Shown here is a
cluster of circulating
tumor cells (red) from a patient with breast cancer.
Circulating
tumor cell (CTC)
clusters — clumps of from 2 to 50
tumor cells that break off a primary
tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.
«Because 85 percent of people in the study reported extending the antenna during calls, we might have expected to find a disproportionate
cluster of
tumors behind the eye and the ear on the side the
cell phone was used since radiation emission is highest at the antenna,» says co-author Mark Malkin, a neuro - oncologist at Memorial Sloan - Kettering Cancer Center.
To understand how these multi-colored lesions originated they examined blood from these mice and found that
tumor cells in circulation frequently occurred as
clusters comprised of different colored cancer
cells.
As
tumors grow and develop, they shed micro-metastases,
clusters of a few
cells that take up residence in far - flung organs such as the brain, liver and bone.
The researchers hope that a better understanding of how Ras proteins
cluster together and interact with other proteins in
cells will bring them one step closer to developing therapeutic targets for Ras - driven
tumors.
When cancer
cells split off from a
tumor to seed deadly metastases, they are thought to travel as
clusters or packs, a phenomenon known as collective invasion.
The software allowed them to
cluster genes into groups associated with specific molecular processes and see which processes in
tumors and blood
cells were associated with each other.
In Nrk mutant mammary glands, dense
clusters of ER alpha - positive mammary epithelial
cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast
tumor.
The Oncogenic Small
Tumor Antigen of Merkel
Cell Polyomavirus is an Iron - Sulfur
Cluster Protein that Enhances Viral DNA Replication.
A cancer
cell is a cabin that wants to expand (
cell growth) and then build a
cluster of additional cabins to create a
tumor (
cell division).
Immediately after the
cells were seeded, each well was checked under the microscope to verify the sparseness of each spherical culture, and only wells containing single -
cell suspension with no
cell cluster were chosen for
tumor - sphere counting after 9 days.
According to recent research, the most common solid
tumors (that is, cancer that occurs as
clusters of
cells in or on organs, rather than in liquid form within the blood or lymphatic system) have up to 66 mutations that influence how the cancer
cells operate — how fast they divide, whether they are susceptible to the signals that would normally cause a
cell to die, when they detach from the main
tumor to colonize another organ in the body, when and where they attach blood vessels to healthy tissues.
Human pathology studies suggest that
tumor cells invade collectively as strands, cords and
clusters of
cells into the stroma, which is dramatically reorganized during cancer progression.
This hematoxylin and eosin stained slide of a surgically removed (resected) primary pancreatic
tumor shows a
cluster of immune
cells (lymphoid aggregate) observed next to a pancreatic
tumor lesion in a patient treated with a GM - CSF vaccine 2 weeks before surgical removal of the primary
tumor.
Through image analysis of breast
tumors and TDLNs, we have found that immune
cell populations as well as their spatial distributions and
clustering patterns have strong correlation with clinical outcome.
LANTCET: elimination of solid
tumor cells with photothermal bubbles generated around
clusters of gold nanoparticles.
These abnormal
cells usually
cluster together to form a
tumor.
Cancerous
cells cluster together to form a mass called a
tumor and can spread throughout the body to other, more distant areas.