Sentences with phrase «tumor cell cycle»

Anil Belur Nagaraj (Bornhäuser, TUD)-- «Understanding the regulation of tumor cell cycle to identify and characterize factors that negatively regulate the tumor phenotype.»

Not exact matches

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

Lee's study results, which appear in the July 16, 2015 issue of Nature Communications, revealed new understanding about how 14 -3-3 sigma — a cell cycle «controller» - regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor - producing factories.

In healthy human cells, the p53 protein helps prevent tumors by putting the brakes on the cell cycle to give an ailing cell time to fix itself — or die — rather than spawning more corrupted cells.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a tumor suppressor and an oncogene (33, 34).

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

The cell cycle regulator p21 mediates the ability of the tumor suppressor p53 to arrest cellular proliferation.

This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb).

Limiting dilution tumor formation of parental, hypoxia - exposed adherent, and cycling hypoxia - selected breast cancer cells in vivo

In tumors, the clockwork genetic mechanisms that control the life cycle of cells are entirely disrupted, a fact that may hold the key to defeating cancer.

Growth curves of primary tumors generated from the parental cell lines and cycling hypoxia - selected subpopulations.

Title: Tumor - initiating cells are not enriched in cisplatin - surviving BRCA1; p53 - deficient mammary tumor cells in vivo Authors: Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P, Rottenberg S Date: 2010 Publication Details: Cell CTumor - initiating cells are not enriched in cisplatin - surviving BRCA1; p53 - deficient mammary tumor cells in vivo Authors: Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P, Rottenberg S Date: 2010 Publication Details: Cell Ctumor cells in vivo Authors: Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P, Rottenberg S Date: 2010 Publication Details: Cell Cycle.

The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double - edged sword.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

CBX2 overexpression in breast tumors was associated with the upregulation of genes involved in cell cycle progression and is associated with poorer 5 - year survival.

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

In cells from certain brain tumors, in stomach cancer, and in colorectal cancer lines, vitamin K halts the reproductive cell cycle and induces apoptosis.

https://www.nature.com/articles/nm.3804 Lee, Changhan et al. «Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy.»

Possible reduction in certain types of cancer: «It appears to work primarily by blocking the growth and metastatic spread of tumors, controlling the cell cycle, and by reducing inflammation.»

Removing the ovaries by spaying the dog before the first heat cycle prevents the release of hormones, thus leaving the breast tissue as a hostile environment for the tumor cells.