Sentences with phrase «tumor cell death in»

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Mogroside V has been found in research to have the ability to inhibit tumor growth in pancreatic cancer by interfering with the rapid dividing of cancer cells, preventing angiogenesis (blood flow to the tumor), and even promoting cancer cell death (10).

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in tumor cells.51, 53

When Hong further boosted MAPK signals and DNA damage in the tumor cells, she found that she could intensify tumor cell death.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

But, counter-intuitively, this mass cell death might be the very thing that makes the animals so long - lived: it could be a natural mechanism their bodies use to clear precancerous cells, stopping tumors in their tracks.

«We conclude that KIF1B - β plays a key role in the decision between life and death for neural crest cells and tumors originating from the neural crest,» says Susanne Schlisio.

The primary cause of death from breast cancer is the spread of tumor cells from the breast to other organs in the body.

The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell.

The researchers conducted genetic tests and found that many of the tumor cells had a mutation in a gene called PPM1D, which causes cells to proliferate and avoid natural death.

But it's much harder to develop therapies that restore malfunctioning genes that should be triggering cell death in abnormal cells, known as tumor - suppressor genes.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung - cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

This is important to avoid missegregation of the genetic material, which may result in cell death or tumor formation.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

The researchers also note that more investigation is needed to fully understand all the mechanisms by which HOXC10 mediates cell proliferation and death, and the roles it may play in different types of tumors.

A section of a tumor organoid grown from cells derived from a patient with high - grade serous ovarian cancer (left) and a mini-tumor treated with ReACp53, resulting in extensive cancer cell death.

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

Genomic data from the HeLa cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical tumor the original HeLa cell line was derived prior to her death in 1951.

«But the antioxidant boosted the ability of the tumor cells to metastasize, an even more serious problem because metastasis is the cause of death in the case of melanoma.

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

The team's experiments in cell cultures, conducted with funding from an American Brain Tumor Association Discovery Grant, showed that coibamide A cuts off the cancer cells» ability to communicate with blood vessels and other cells, eventually starving the cell and triggering its death.

The drug caused a 50-fold increase in brain tumor cell death.

Considerable previous research in cell cultures has demonstrated that low doses of ionizing radiation results in «bystander» effects, in which nearby, unexposed tissues suffer cell death, mutations, and tumor - inducing growth (ScienceNOW, 7 September 2005).

Previous studies show that antibody treatments that inhibit the protein, called programmed cell death 1 (PD - 1), can shrink tumors in humans.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwidIn a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwidin esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.

As an initial focus, researchers at Chicago will search for novel ways to take advantage of steroid hormones and their receptors to detect metastases, define their boundaries and deliver treatments directly to tumor cells in order to inhibit cell division or promote cell death.

Researchers at the University of Chicago noted that in recent years, genetically engineered herpes simplex virus studied for its efficacy against malignant tumors of the central nervous system and the liver was blocking certain types of cell death and proliferation of surviving cells.

In a very interesting paper published in Molecular Cell (PMC4530630) they showed that SBI - 0206965 inhibits autophagy and activates cell death in tumor cells resistant to mTOR inhibitorIn a very interesting paper published in Molecular Cell (PMC4530630) they showed that SBI - 0206965 inhibits autophagy and activates cell death in tumor cells resistant to mTOR inhibitorin Molecular Cell (PMC4530630) they showed that SBI - 0206965 inhibits autophagy and activates cell death in tumor cells resistant to mTOR inhibitCell (PMC4530630) they showed that SBI - 0206965 inhibits autophagy and activates cell death in tumor cells resistant to mTOR inhibitcell death in tumor cells resistant to mTOR inhibitorin tumor cells resistant to mTOR inhibitors.

Tumor sizes decreased in the treated mice, areas of cell death were visible, and all AAV2 treated mice survived through the study, a direct contrast to the untreated mice.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Finally, loss of FANCD2 in BRCA1 / 2 - deficient tumors enhances cell death.

Stimulation of TRAIL protein is sustained in both tumor and normal cells, with the normal cells contributing to the TIC10 - induced cancer cell death through a bystander effect.

The Altieri laboratory is interested in how tumor cells evade apoptosis — also known as programmed cell death — which is the process that normally causes dysfunctional cells to self - destruct.

The King Lab has pioneered the use of selectin proteins to deliver apoptosis death signals to tumor cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes.

Interestingly, fluid shear stress also modulates how tumor cells respond to apoptosis death signals in the bloodstream.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

Further studies showed that Notch1 knockdown in NSCLC helps induce cell death (which inhibits tumor initiation and growth); this process is mediated by p53, and thus the effects of inhibiting Notch1 require functional p53.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

Swanton's new lab set out to identify specific genes that, when inhibited, result in the death of tumor cells that displayed aneuploidy, meaning they had more or less than the normal set of 46 chromosomes.

Dr. Altieri also leads a research program that studies how tumor cells evade programmed cell death and the role of mitochondria, power plant of the cells, in tumor metabolism.

The drugs reduce pain and inflammation by inhibiting the cyclooxygenase (COX) enzymes, which are involved not only with inflammation but also with certain processes involved in cancer, such as blood supply to the tumor and programmed cell death (known as apoptosis).

The most famous, oldest, and most commonly used immortal cell line, dubbed HeLa, originated in a tumor sample taken from an African - American woman, Henrietta Lacks, who is the subject of the recent book The Immortal Life of Henrietta Lacks.9 The tumor cells, harvested at Johns Hopkins Hospital, gave rise to the eponymous HeLa cell line which researchers have used continuously since her death in 1951 for numerous experiments, including Jonas Salk's development of the polio vaccine.

Pterostilbene, found exclusively in blueberries, has been shown in studies to induce apoptosis — programmed cell death — of malignant cells, and to act against tumors.

In one study (1), prostate cancer patients who added about 3 heaping tablespoons of ground flaxseed daily to their diet, had more slowly - dividing tumor cells and a greater rate of tumor cell death than men who did not follow such a diet, after about 5 weeks.

In the laboratory animal study, ursolic acid, the active compound in holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alonIn the laboratory animal study, ursolic acid, the active compound in holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alonin holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alone.

In a laboratory study published in 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellIn a laboratory study published in 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellin 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellin Oncology Reports, chokeberries caused the death of malignant brain tumor cells.

And, though they were skeptical that they would observe any difference in tumor biology in the diet - treated patients with such a short - term dietary intervention, just within those few weeks, they found significantly lower cancer proliferation rates, and significantly higher rates of cancer cell death.

(Source) Another study found lyophilized strawberries to inhibit oral tumorogenesis in hamsters (source), while a different study investigated the effects of strawberry extract on leukemia and breast cancer cells, and discovered the extract to inhibit tumor proliferation by causing cell death.

Multiple studies in laboratory's show that curcumin can reduce the growth of tumors, the spreading of cancer, and contribute to overall cancer cell death.