Sentences with phrase «tumor cell diversity»
The work also showed that tumors with high chromosomal instability, which can lead to tumor cell diversity through chromosomal rearrangements, are least sensitive to these chemotherapies.
https://www.the-scientist.com/ Not exact matches
«Their immune systems may be less poised to detect foreign tumor cell grafts, compared to other species that have more genetic diversity.»
«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.
Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.
Their analysis showed that the diversity of T - cell receptors decreased among samples of T - cells taken closer to the tumor, compared with farther away.
The first is genetic heterogeneity, which is the diversity of genetic phenotypes within a group of tumor cells.
The technology successfully tracked in real - time how the diversity of tumor cell populations were changing in response to particular therapies for all of the patients studied, and was highly predictive of treatment effectiveness and patient outcomes.
Now, scientists at the Salk Institute have uncovered details about how cancer is able to become drug resistant over time, a phenomenon that occurs because cancer cells within the same tumor aren't identical — the cells have slight genetic variation, or diversity.
The most rigorous genetic sequencing ever carried out on a single tumor reveals far greater genetic diversity among cancer cells than anticipated.
«In a setting with so much diversity, those cells could multiply to form new tumors, which would be resistant to standard treatments.»
Single - cell DNA solid tumor profiling enables high resolution of the genomic diversity in a variety of tumor types.
Taken together, our results provide for the first time the evidence of the biological significance of IRF - 9 / STAT2 complex, and furnish an alternative pathway modulating the expression of IFN - stimulated genes, contributing to the diversity of IFN signaling to mediate their multiple biological properties in normal and tumor cells.
We furnished here an alternative pathway for the diversity of IFN signaling to mediate its multiple biological properties in normal and tumor cells.