Sentences with phrase «tumor cell genome»

A Chinese research team has now developed a gold - nanoparticle - based multifunctional vehicle to transport the «gene scissors» to the tumor cell genome.

The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.

Not exact matches

To determine how the cells switch from one type to another, they took three human uterine carcinosarcoma samples and sequenced the genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greene said.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Mutations transform the genome of a tumor; its cells become genetic outlaws that spread, ignore normal stop - and - go signals and evade cancer - killing drugs or radiation.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.

Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome.

By performing a genome - wide screen in breast cancer cells, Dr. Oesterreich and her colleagues identified a gene called HOXC10 as one that the cancer seems to modify to allow continued tumor growth in patients whose cancer becomes resistant to traditional therapies.

Without the genome sequence of Lacks» healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

The National Institutes of Health today announced in Nature that it has reached an understanding with the family of the late Henrietta Lacks to allow biomedical researchers controlled access to the whole genome data of cells derived from her tumor, commonly known as HeLa cells.

They used the gene - editing CRISPR / Cas9 technique to sift the genomes of melanoma cells for changes that made tumors resistant to being killed by immune T cells, which are the main actors in the immune system response against infections and cancer cells.

As the cost of DNA sequencing continues to plummet, the lab will move ever closer to a once - elusive goal: economically processing every patient's complete genome in both tumors and healthy cells.

Future additions to the RM collection may include whole genomes from persons with Hispanic, African and mixed ancestries, as well as a set containing sequenced genes of both malignant tumor and normal cells from the same individual.

Polyploid cells, which carry additional copies of important tumor suppressor genes, are better protected and more resistant to cancer formation because they have these extra copies of the genome,» said Dr. Zhu, who is also an Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Atlas.

But by sequencing the entire genomes of seven prostate tumors and comparing them with genomes from the patients» normal cells, the researchers discovered an unexpected phenomenon.

His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.

«Why premature cell division promotes cancers: Researchers have discovered how genes responsible for cell division, when mutated, disrupt the replication process of the genome and promote tumor formation.»

Sequencing the genomes of tumor cells has revealed thousands of genetic mutations linked with cancer.

These include genome instability / mutation, which they discussed previously, and tumor - promoting inflammation, mediated by immune system cells that are recruited to the site of a developing tumor.

We developed SomaticSniper to detect somatic mutations in whole - genome sequencing data while allowing for tumor contamination of normal cells that occurs in some types of leukemia.

Deciphering how large genes impact CFS instability is therefore crucial to our understanding of genome remodeling in tumor cells.

In cancer research, the «Cas -9-sgRNA» complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved.

And when viruses containing the four genes insert themselves into the genomes of skin cells, they can activate innate cancer genes and cause tumors.

For this compilation, I've emphasized publications in which whole - genome or exome sequencing was employed to multiple tumors or cancer cell lines, with the goal of identifying significantly altered genes or pathways in malignant cells.

For some types of cancer, the existence of certain subtypes had not been known until researchers began to profile the genomes of tumor cells.

Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single - Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.

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The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.

«Multiclonal invasion identified in early breast tumors by topographic single cell genome sequencing»

A genome - wide study of allelic imbalance in human testicular germ cell tumors using microsatellite markers.

Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome - wide in human tumor cells.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.

Tumor cells carry a unique set of mutations in its genome that alter normal cell functions.

Studies The Puppy Up Foundation helped fund with The Broad Institute: Title of Study: Osteosarcoma Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard Title of Study: Mast Cell Tumors Grant Awarded: $ 20,000 Principal Investigator: Kerstin Lindblad - Toh Scientific Director of Vertebrate Genome Biology at the Broad Institute Broad Institute of MIT and Harvard