This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that
tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.
University of Hawai'i Cancer Center researchers have identified an essential driver of
tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.
The researchers have shown that this marker protein changes myoepithelial cells in breast tissue to promote
tumor cell invasion in vitro and enhances mammary tumor growth in vivo.
A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of
tumor cell invasion in glioblastoma.
Not exact matches
Published
in the February 27 issue of
Cell, the study found that
tumor cells that reach the brain — and successfully grow into new
tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic
invasion.
«By understanding how stress accelerates
invasion in aggressive breast
tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy
in the treatment of some aggressive breast cancers.»
«This finding suggests a novel therapeutic target to decrease
invasion of
tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.
In the laboratory they showed how morphine can increase proliferation, migration and
invasion of
tumor cells.
Unrestrained epithelial
cell extrusion has been linked to
tumor cell invasion and metastasis
in other studies.
However, when these myeloid
cells migrate to
tumor sites, they can differentiate to
tumor associated macrophages (TAMs), which can
in turn stimulate the formation of blood vessels
in tumors and promote enhanced
tumor cell invasion and motility.
In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling,
cell adhesion and cytoskeleton dynamics required for
tumor invasion.
Thus,
in a panel of breast cancer samples, we identified
tumor cells that did not form part of the bulk
tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer
cell invasion.
We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing
in the
tumor initiation, maintenance, and
invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways
in stemness and migration of these
tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.
Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics
in complex soil structure, brain
tumor growth and
invasion, formation of complex bacterial colonies, and changes
in blood vessels and skin
cells.
STC2 overexpression could promote
tumor cell proliferation,
invasion, and metastasis
in prostate cancer, ovarian cancer, or neuroblastoma.
The epithelial - to - mesenchymal transition (EMT) and the reverse process (the mesenchymal - to - epithelial transition [MET]-RRB- have been shown to be associated with
tumor cell invasion and metastasis
in different carcinomas.
Through its various targets, MMP1 promotes not only
tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from
tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression
in osteoblasts, which
in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced
tumor growth
in the bone microenvironment (32).
Finally,
in collaboration with physicists from the Institute Curie, we are also investigating if,
in addition to cellular and biochemical
tumor microenvironment, mechanical pressure imposed by stroma can stimulate
invasion of cancer
cells.
Carcinoma - associated fibroblasts (CAFs) are a highly enriched
cell population
in the
tumor microenvironment that plays an important role
in cancer
invasion.
«Multiclonal
invasion identified
in early breast
tumors by topographic single
cell genome sequencing»
Tumor hypoxia is often linked to decreased survival
in patients with breast cancer and has been shown to induce specific molecular changes
in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4),
invasion (5), and metastasis (6).
«consumption of abundant alkaline - forming foods can result
in improvement
in bone mineral density (BMD) and muscle mass, protection from chronic illnesses, reduced
tumor -
cell invasion and metastasis, and effective excretion of toxins from the body.
The first step is to tunnel through the surrounding matrix, considered «a critical event
in tumor cell invasion.»
They help block the ability of cancer
cells to produce the
tumor invasion enzyme
in the first place,
in both human colon cancer
cells, and human breast cancer.