Not exact matches
For this study, a
tumor cell line was transplanted into a rat and imaged with each of the following: conventional MRI, the radiotracer carbon - 13 (C - 13) pyruvate and hyperpolarized MRI
at a resolution of 2.5 mm, Medipix positron detector, luminescence sensor and a fluorescence microscope.
But in
at least one case, a small
tumor merged with the
cells lining the faux blood vessel.
Earlier approaches to creating this growth environment, pioneered by study co-author Jason Spence, Associate Professor of Internal Medicine
at the University of Michigan, had used a natural matrix derived from a
tumor cell line.
Researchers studying the brain
tumor type glioma often use a
cell line called U87MG that was established
at Uppsala University almost fifty years ago.
Researchers
at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on
cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal
tumors.
Timothy Wang
at Columbia recently published work in Cancer
Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the
tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that
line the stomach could represent a novel therapy.
In an effort to overcome these limitations, a team
at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which
cells from a human intestinal
cell line originally isolated from a
tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial
cells in the adjacent channel.
The three Group 3 medulloblastoma
cell lines used in this study reinforced the observation, highlighting significant differences in epigenetic regulators
at work in medulloblastoma
cell lines versus
tumor samples.
«By using an animal model to expand
tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial
cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer
at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.
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Since starting her new role as an investigator in the In Vivo Pharmacology group
at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in
cell line and primary
tumor xenograft models.
Most xenograft models for brain
tumors using
tumor cell lines require
at least 10,000
cells.
In the latest issue of the magazine EBioMedicine researchers
at SciLifeLab / Uppsala University present a biobank with
cell lines that can be used as models for brain
tumors.
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human
tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma)
at clinically achievable concentrations.
The most famous, oldest, and most commonly used immortal
cell line, dubbed HeLa, originated in a
tumor sample taken from an African - American woman, Henrietta Lacks, who is the subject of the recent book The Immortal Life of Henrietta Lacks.9 The
tumor cells, harvested
at Johns Hopkins Hospital, gave rise to the eponymous HeLa
cell line which researchers have used continuously since her death in 1951 for numerous experiments, including Jonas Salk's development of the polio vaccine.