Sentences with phrase «tumor cell proliferation»

«In our study, we demonstrated that alpha - KGDH, when coupled with Gcn5, induces histone succinylation and promotes tumor cell proliferation and tumor development.»

Phytochemicals in 50 mg apple without skin per milliliter inhibit tumor cell proliferation by 23 %.

Phytochemicals in 50 mg apple with skin per milliliter (on a wet basis) inhibit tumor cell proliferation by 42 %.

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

«These findings underscore the significance of Gcn5 - regulated gene expression coupled with the metabolic enzyme alpha - KGDH in tumor cell proliferation and formation.»

According to University of Helsinki scientist and Finnish Academy Research Fellow Juha Klefström, PhD, who led the study, «Myc oncoprotein not only boosts tumor cell proliferation but it also makes the cells vulnerable to cell suicide program, apoptosis.

While investigating a potential therapeutic target for the ERK1 and 2 pathway, a widely expressed signaling molecule known to drive cancer growth in one third of patients with colorectal cancer, University of California San Diego School of Medicine researchers found that an alternative pathway immediately emerges when ERK1 / 2 is halted, thus allowing tumor cell proliferation to continue.

The new results of this study imply, that the suppression of telomerase activity may immediately stop tumor cell proliferation.

Researchers link slipshod construction of chromosomal termini to unregulated tumor cell proliferation

Inhibit key enzymes in cancer cell specific metabolic pathways to disrupt tumor cell proliferation and survival

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

STC2 overexpression could promote tumor cell proliferation, invasion, and metastasis in prostate cancer, ovarian cancer, or neuroblastoma.

We found that the phytochemical extract of the whole food — apples — strongly inhibited tumor cell proliferation.

Dr. Gollnick's laboratory explores how tumor cells co-opt the host immune system to promote chronic inflammation that leads to increased vascularization, suppression of anti-tumor immunity and increased tumor cell proliferation and migration.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

They include its effects on endothelial cell «differentiation» to yield tubular - like structures, endothelial and tumor cell proliferation, apoptosis, and migration, as well as its effects on extracellular matrix remodelling enzyme activities of matrix metalloproteinase - 2 (MMP - 2) and urokinase - type plasminogen activator (uPA).

Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC - associated factor X. Qin N, de Cubas AA, Garcia - Martin R, Richter S, Peitzsch M, Menschikowski M, Lenders JW, Timmers HJ, Mannelli M, Opocher G, Economopoulou M, Siegert G, Chavakis T, Pacak K, Robledo M, Eisenhofer G. Int J Cancer.

It promotes tumor cell proliferation and resistance to apoptosis (programmed cell death after a certain number of cell divisions, a good thing when it comes to cancer cells).

The apple extracts with skin significantly reduced the tumor cell proliferation when compared with the apple extracts without skin.