Sentences with phrase «tumor cell recognition»

Shed NKG2D - L, due to proteolytic cleavage by disintegrin / metalloproteinases as ADAM10, can impair tumor cell recognition.

Not exact matches

Zelig Eshhar and colleagues first use the T - body approach, employing chimeric receptors composed of an antibody recognition unit linked to T cell activation domains, to redirect T cells to recognize and attack tumor cells.

«We have experiments in mice that show that the combined use of PD - 1 antibody and poly - IC is synergistic for the recognition of tumors and an antitumor response mediated by T - cells,» says Dr. Esteban Celis, co-leader of the Cancer Immunology, Inflammation and Tolerance program at the Georgia Cancer Center at Augusta University.

Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.

Toxicity is a significant concern with CAR T - cell therapies, since they have the capacity to elicit not only expected serious adverse events but also unexpected ones, including cytokine release syndrome (CRS), neurologic toxicity, «on target / off tumor» recognition, and anaphylaxis.

Central to the concept of immunoediting is the idea that T - cell recognition of tumor - specific antigens drives the destruction of early tumors, and later the antigenic «sculpting» of persistent tumor cells.

Michelle Barton, Ph.D., was nominated and elected by her scientific peers in recognition for her contributions to understanding the function of the tumor suppressor, p53 in stem cells, particularly with respect to the discovery of TRIM24, an E3 - ligase and epigenetic regulator that is overexpressed in many cancers.

Matsuzaki J, Tsuji T, Luescher I, Old L, Shrikant P, Gnjatic S, Odunsi K. (2014) Non-classical antigen processing pathways are required for MHC class II - restricted direct tumor recognition by NY - ESO -1-specific CD4 + T cells.

Tsuji T, Matsuzaki J, Caballero OL, Jungbluth AA, Ritter G, Odunsi K, Old LJ, Gnjatic S. (2012) Heat shock protein 90 - mediated peptide - selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4 + T cells.

Specifically, some tumor cells appeared to express PD - L1, essentially «wrapping» themselves in it to avoid immune recognition and destruction.

A primary function of CTLs is the selective recognition and destruction of tumor cells.