Sentences with phrase «tumor cell surfaces»

Another lab ran into a similar problem when it tried to replicate work by Stanford stem cell biologist Irving Weissman and his colleagues, who reported in 2012 in the Proceedings of the National Academy of Sciences that an antibody to a tumor cell surface receptor called CD47 can slow tumor growth in mice.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

Many tumors release cells with distinctive antigens on their surfaces, and affinity - based techniques can pull these cells out of the blood sample relatively easily.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR - T cells.

SapC - DOPS binds with exposed patches of the phospholipid phosphatidylserine (PtdSer) on the surface of tumor cells;

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Instead of displaying the full complement of incriminating proteins on the tumor cell's surface, the dog cancer displays just a few, obfuscating the invasion underway.

The tumor cells» surfaces presented no antigens and thus, no identity card at all.

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

Images of the tumor cells are immediately created on an LCD screen observed as the surgeon scans the instrument across the tumor or brain surface.

The protein sits on the surface of T cells and helps dampen the activity of the cells after an immune response, but tumors have found ways to hide from T cell attack by flipping on the PD - 1 switch themselves.

The tool sprays a microscopic stream of charged solvent onto the tissue surface to gather information about its molecular makeup and produces a color - coded image revealing the nature and concentration of tumor cells.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

The ability to track tumor cells in the bloodstream based on genetic content located within the cell itself, as opposed to using proteins located on the cell's surface (current technology)

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Using microfluidic design principles, Liu's group engineered vortices in their device to increase the chance that tumor cells will collide with the surface of the flow channel.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

Since cancer cells bear very specific antigens on the surface, the corresponding antibodies bind to these molecules and thus inhibit tumor growth.

While fibers aligned perpendicular to the surface of the tumor provide a path for the tumor cells to follow and encourage spreading.

IL - 6 is a cytokine, a signal molecule that is produced and secreted both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.

But the full potential of CARs for treating solid tumors has not been reached because they have targeted molecules found on the surface of both normal cells and cancer cells, resulting in serious side effects.

Working in mouse models of breast cancer and breast tumor samples from patients, Longmore and his colleagues showed that a protein that sits on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.

F3 can detect the expression of a protein called nucleolin, which is a marker on the surface of tumor cells.

Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.

Pembrolizumab blocks the action of the tumor - surface protein PD - 1, which many cancers use to hide themselves from immune system T cells.

In breast cancer, CSCs or tumor - initiating cells were first identified by using a combination of cell surface markers, CD24 − / CD44 + / ESA (EpCAM) + (2).

Hu14.18 K332A is a laboratory - produced antibody designed to activate the immune response against tumor cells by recognizing and binding to an antigen found on the surface of most neuroblastoma tumor cells.

Although there is new data coming from Dr. Michel Sadelain's lab and others where they have made a molecule that may work as a CAR T cell that would then bind to NY - ESO - 1 peptides displayed on the surface of a tumor cell.

The serologically unique cell surface antigen of Zajdela ascitic hepatoma is also its tumor - associated transplantation antigen.

Once the sensors have traveled into a tumor's leaky blood vessels, they use special targeting molecules to bind to receptors on the surface of blood vessel cells.

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

Specifically, they analyzed the tumors» epigenome, an array of molecules that covers the surface of DNA and helps regulate gene activity, acting like a control switch to decide which genes are active or inactive in the cell.

Recently, there has been progress in the treatment of patients with malignancy through targeting receptors on the surface of CD8 + T cells that inhibit their activity within the highly suppressive tumor microenvironment.

Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell proliferation, suggesting a possible mechanism for how HYAL2 might be involved in tumor formation.

Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

Through a genetic screen in Drosophila, Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

From there they showed that cancer cells had lost structural polarity, resulting in random distribution of CAR receptors on their surface, thereby allowing the virus to attach to and infect the tumor cells.

We have invented new biomaterial surfaces based on natural halloysite nanotubes, that capture rare circulating tumor cells (CTCs) from blood while simultaneously repelling white blood cells.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

Metastatic tumors develop when cancer cells spread from another area of cancer by breaking away from the primary tumor and traveling through the body by way of the blood, lymphatic vessels or membranous surfaces.

Most of these CSCs have been identified using surface markers that identify their corresponding normal tissue stem and progenitor cells, thus reinforcing the resemblance of tumor development to normal organogenesis.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.