Sentences with phrase «tumor cell survival»

Results from earlier reports and this study support the hypothesis that the PI3K - AKT - mTOR pathway contributes to tumor cell survival in ALCL as shown in this proposed model.
Hypoxia - induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma.
These data suggest that ABL kinases promote breast cancer metastasis to bone in part by increasing tumor cell survival within the bone microenvironment.
Bin Hu, PhD, senior postdoctoral scientist on Fisher's team discovered that the interaction between the AEG - 1 and Akt2 proteins was critical for further Akt2 signaling, which regulates tumor cell survival, proliferation and invasion.
Direct Transcriptional Up - regulation of Cyclooxygenase - 2 by Hypoxia - Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during Hypoxia
The VHL - HIF - 1 axis is of great interest overall, as cancer cells often reside in a low - oxygen milieu and upregulate HIF to establish a glycolytic state favoring tumor cell survival.
Our work provides the basis for a novel drug that will treat resistant cancer by cutting off a main tumor cell survival process.»
These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.
IL - 6 has pleiotropic roles during tumor progression and metastasis that include increased tumor cell survival, expansion of breast cancer stem cells, and resistance to targeted therapies (52).
Using tumor cells from DLBCL patients, the scientists discovered that the inactivation of BTK in resistant tumors triggers the over-activation of alternative signals that promote tumor cell survival and proliferation.
Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase — Positive Anaplastic Large Cell Lymphoma
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