Sentences with phrase «tumor cells break»

During this invasion, the tumor cells break down the proteoglycans that are found on and between the cells.

Not exact matches

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

If the tumor that Jobs had removed in 2004 had begun to break down prior to the surgery, White says, the tumor's dead cells could have released protease and lipase enzymes that may have damaged beta cells in the pancreas, which produce insulin.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

To migrate from a primary tumor, a cancer cell must first break through surrounding connective tissue known as the extracellular matrix (ECM).

The investigators found that when working through an environment with no pre-existing tracks, tumor cells had to actively stick to the tissue, break it down and then move themselves forward.

Cells suspended in a stiff matrix were more likely to work their way through the matrix to other side of a serum gradient, analogous to how metastasizing cancer cells break free from their tuCells suspended in a stiff matrix were more likely to work their way through the matrix to other side of a serum gradient, analogous to how metastasizing cancer cells break free from their tucells break free from their tumors.

Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.

ON THE ROAD Breast cancer cells may break away from the main tumor in clumps, already bearing most of the mutations that will drive cancer recurrence, a study suggests.

Comparing the metastasized tumors with the original breast tumors, the researchers were surprised to learn that multiple, slightly genetically different cells from the original site had broken away together and established the new tumors.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

«These are the cells that can break away from a tumor and metastasize; these are the cells you most want to kill with chemotherapy.

Eventually some tumor cells may break off and establish new growths (metastases) at distant sites.

Then tiny clumps of cancer cells broke away from the tumor and floated away in the fluid flowing through the capillary.

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor - seeding cells, according to a new University of Illinois study.

Metastasis is the process in which cells from a primary tumor break - off, enter the blood stream and create new tumors elsewhere in the body.

This allows cancer cells to break off from tumors, spread throughout the body (in blood or other fluid) and form new tumors at distant sites — a process called metastasis.

These tumors might yield to a new kind of drug known as a PARP inhibitor that kills cancer cells by hijacking the cell's ability to mend DNA breaks.

As described in a study posted online May 21 by Science magazine, the strategy uses tumor cells» own protein - chopping machinery to break down and dispose of proteins that drive cancer growth.

When such DNA damage occurs, proteins known as PARPs move to the site of damage and begin to mend these broken strands of DNA, allowing cancerous cells and tumors to recover, grow and proliferate, thereby escaping the effects of treatment.

The pathway then uses the tumor's metabolism to break down glucose and use its energy to reduce cell death and maintain proliferation.

For this purpose, they use certain enzymes, proteases that break down the tissue surrounding the tumor, thus opening the way for tumor cells to reach blood or lymphatic vessels.

These cells are thought to break off from the original tumor and circulate in the blood, and may be a sign of an aggressive tumor.

Tumors with high levels of E-cadherin tend to be tightly tethered to nearby cells and less likely to break free and travel to other sites.

The researchers have devised a nanosensor that breaks apart in the presence of ovarian tumor cells and sheds fragments of itself.

If the cell can't fix the DNA break, it will induce cell death — a self - destruct mechanism that helps to prevent mutated cells from replicating (and thus prevents tumor growth).

These reduceable linkages have the advantage that inside the tumor cell, the bonds would be broken by glutathione, a natural reducing compound enriched in tumor cells.

Scientists also recognized that cancer cells that «want» to spread learn how to use TGF - β wound - healing function to break from a tumor, he says.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

An initial payload of CD8 cells breaks down the tumor, and the HSC - derived CD4 cleans up the remaining cells and acts as protection against the recurrence of any cancer cells expressing NY - ESO - 1.

Their technique has shed light on how cells repair DNA strand breaks, which could help scientists learn how to protect astronauts from cosmic rays as well as refine radiotherapy protocols designed to kill tumors.

When tumor suppressor genes work properly, they «slow down cell division,» repair broken DNA, and trigger programmed cell death.

Metastatic tumors develop when cancer cells spread from another area of cancer by breaking away from the primary tumor and traveling through the body by way of the blood, lymphatic vessels or membranous surfaces.

The anticoagulant property might prevent cancerous cells that break away from tumors from sticking to other areas in the body and growing into metastatic tumors.

Working with James Hicks, a biologist at USC, the team was able to detect tumor DNA in tiny fragments that had likely been loosed as tumor cells died and broke up.

These cancer cells break away from the initial tumor and spread to other parts of the body.