Sentences with phrase «tumor cells containing»

He soon managed to restrict the growth factor to a fraction of the tumor cells containing both protein and nucleic acid.

Results showed that tumor cells containing the protein carried anywhere from 10 to 17 times fewer breast stem cells, and tumors grown from the injected cells were about three times smaller than those in mice who had received tumor cells with depleted levels of HOXA5.

If we are able to keep the tumor cells contained and let them fight it out, we would expect to see more competitively fit cells that are growing very slowly.»

Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.

Cell - staining revealed that the tumor cells contained no functional RNase L, the group reports in the February issue of Nature Genetics.

Not exact matches

Strawberries also contain fisetin, which halts the growth of cancerous cells while diminishing tumors» blood supply.

Cauliflower contains sulforaphane, a sulfur compound that is shown to kill cancer stem cells and slow tumor growth.

Even after initial purification of the sample, liquid biopsies typically contain much more nucleic acid from healthy cells than from tumors.

The diagnosis of cancer and study of disease progression is often accomplished by examining a tumor sample containing many billions or even trillions of cells.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Another challenge is producing stem - cell - derived tissues or organs that don't develop teratomas — tumors that contain a variety of tissues found in different organs — when transplanted.

According to the head of the research group of chemoresistance and Predictors of tumor response and stromal environment ICO - IDIBELL, Alberto Villanueva, «tumor exosomes contain certain proteins (Dicer, TRBP and Ago2) able to process microRNAs that can alter the around the tumor cells transforming them into tumoral cells.»

The arithmetic is complex, but the consensus is that, to pose a health threat, cancers have to replicate at least 200 to 300 times, even though a clinically relevant tumor contains «only» a million million cells, which could be achieved by «only» 40 or so divisions if the originating cell had all the necessary mutations from the outset.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

«Aggressive cancers contain regions where the cancer cells are starved for oxygen and die off, yet patients with these tumors generally have the worst outcome.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

Achieving this goal has been hampered by the technical difficulty of isolating pure cancer cells out of the tumor tissue that contains both tumor cells as well as normal cells.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

The study showed that mice implanted with breast cancer cells lacking the protein developed small, self - contained tumors consisting of cells that didn't leave the tumor.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

Olaparib had no effect on tumors formed by breast cancer cells containing functional BRCA1 and BRCA2 genes.

If the signaling error occurs before the cells have differentiated to become either bone or hair or skin, the result can be a teratoma, a tumor that contains a jumble of cell types.

Cranberries also contain a number of compounds that benefit human health — including some that have been shown to inhibit the growth of tumor cells — and sequencing work may reveal more about them.

Tumors, for example, are known to contain different populations of cells, some of which are quite different to each other in their genetic makeup.

Researchers believe that if the body contains enough of the protein, the immune system will recognize it as a potential danger and send out armies of disease - killing cells to seek and destroy tumors harboring it.

«We have found that the individual cells within melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Research Center.

That is, they contained multiple populations of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing tumors to survive drug therapy.

Dying cells in a tumor (upper left) or damaged tissue release DNA fragments that course through blood and that contain markers that point to their origin in the body.

The study showed that the tumor cells only contain one cilium and have disrupted Sonic Hedgehog signaling, which drives tumor - cell growth.

The researchers found that the tumors had lost these mutations by various means, including immune - mediated elimination of cancer cells containing these mutations, leaving behind cancer cells without the mutations, or by deleting large regions of their chromosomes in all cancer cells.

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

Cells of the latter cancer types contain many DNA mutations, which are thought to make distinctive «neoantigens» that help the patient's immune system recognize and attack tumors, and make the cancer cells» «microenvironment» hospitable to tumor - fighting T cCells of the latter cancer types contain many DNA mutations, which are thought to make distinctive «neoantigens» that help the patient's immune system recognize and attack tumors, and make the cancer cells» «microenvironment» hospitable to tumor - fighting T ccells» «microenvironment» hospitable to tumor - fighting T cellscells.

The tumor becomes differentiated, its cells now cyst - like and filled with fluid that contains, among other things, milk proteins.

Future additions to the RM collection may include whole genomes from persons with Hispanic, African and mixed ancestries, as well as a set containing sequenced genes of both malignant tumor and normal cells from the same individual.

tumors from neural stem cells also contained more glioblastoma stem cells, cells that are believed to give rise to tumor recurrence after therapy,» says Lene Uhrbom, senior lecturer at the Department of Immunology, Genetics and Pathology and lead author of the study.

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.

Once the T cells contained the new, tumor - specific receptors, the scientists infused the T cells back into the blood of each patient.

Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.

One idea the team is mulling is to implant in patients a bag of iPS - derived liver cells that are self - contained, so they can't seed tumors in a patient's tissues but can still produce A1ATD.

All of these foods contain the inositol phosphate IP5 — a compound that even at low dose limits the supply of blood to tumor cells and inhibits tumor growth in mice, according to new findings.

Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance.

The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

«Our results show that not only do exosomes enhance the phenomenon of the «Warburg effect» in tumors, but exosomes also contain «off - the - shelf» metabolites within their cargo that cancer cells use directly in their metabolic processes,» Zhao said.

The fusion partner, the other part of the CAR, contains the business end — it's basically the engine that activates the T cell and tells it to kill the tumor cell that it's bound to, and also makes the T cell proliferate.

Researchers studying the heterogeneous nature of cancer stem cell - containing skin tumors may have discovered new therapeutic targets

In another experiment, treating human brain cancer cells containing FGFR3 - TACC3 with mitochondrial inhibitors interrupted the production of energy inside cancer cells and significantly slowed tumor growth.

Because brain tumors contain an unusually diverse mix of cells, our plan of attack is diverse as well.

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

Tumors also release microparticles containing PS, ultimately suppressing immune response to the tumor by keeping the host's immune system busy fighting particles and dead cells.