Sentences with phrase «tumor cells in a culture»

The research highlights the importance of studying the effects of drugs not only on the tumor cells in a culture plate, but also on the interaction of the tumor cells with their own microenvironment.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

Not exact matches

In 2010, researchers from the University of Michigan Comprehensive Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cellIn 2010, researchers from the University of Michigan Comprehensive Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cellin the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cellin mice and in lab cultures, and it also prevented the growth of new tumor cellin lab cultures, and it also prevented the growth of new tumor cells.

CCG is also developing cell lines that are cultured to represent tumor behavior in vivo, and computational methods that will help researchers understand tumor behavior and apply the resulting data to diagnoses, treatments, and cures.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellIn a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellin cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cellin differentiated tumor cells.

Oncologists William Hahn, Robert Weinberg, and colleagues at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part of the enzyme and inserted it into cultured human cells from colon, ovary, and breast tumors.

Indeed, after Siddle added a squirt of interferon - gamma — a chemical messenger that activates numerous genes involved in producing MHC antigens — to cells cultured from devil tumors, the MHC genes functioned normally again, and the tumor cells» identity cards showed up, plain as day.

Until recently, Ain was renowned for a highly prized repository of 18 immortal cancer cell lines, which he developed by harvesting tissue from his patients» tumors after removal, carefully culturing them to everlasting life in vials.

The substance vigorously inhibited the growth of cultured tumor cells from colon, lung, and breast cancers, the team reports in the 20 January issue of Angewandte Chemie.

The virus kept turning cultured cells cancerous, and it kept causing tumors in animals.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeareIn the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appearein the tumor the stem cells appeared.

This soluble factor was found at higher levels in the blood of animals with lung tumors, could increase the activation of osteoblasts and contributed to the maturation of neutrophils in cultured cells.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

A major challenge in creating any type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient tumor cells into miniature tumor organoids in a petri dish.

In contrast to other cultured cells, such tumor cells can divide indefinitely and a cell line can therefore be cultured for many years.

An important approach in advanced cancer medicine is to treat cancer using a patient's immune cells after first arming the cells against the tumor in culture.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channeIn an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein the adjacent channel.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

The team conducted additional experiments in which mouse breast tumors were sampled to generate so - called organoids — spheres of cells that grow in three - dimensional culture.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

The team's experiments in cell cultures, conducted with funding from an American Brain Tumor Association Discovery Grant, showed that coibamide A cuts off the cancer cells» ability to communicate with blood vessels and other cells, eventually starving the cell and triggering its death.

Considerable previous research in cell cultures has demonstrated that low doses of ionizing radiation results in «bystander» effects, in which nearby, unexposed tissues suffer cell death, mutations, and tumor - inducing growth (ScienceNOW, 7 September 2005).

The immortalized endothelial cell lines established from H - 2Kb - tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems.

The tumor cells were dissociated and the cells were infected with KLF4 lentivirus and cultured in low - attachment plates.

AHERF Neurosciences Grant (G9410 -020-Y01)- Co-PI; «Differential expression and sorting of the neuron - specific class III b - tubulin isotype in human neuronal and neuroendocrine tumor cell lines maintained in an organ culture system».

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

We found that canonical signaling by the EphB4 receptor is low in breast cancer cells and that ephrin - induced stimulation of EphB4 kinase activity inhibits breast cancer cell malignancy in culture and tumor growth in vivo (Figure 1A) through inhibition of the CRK proto - oncogene.

Briefly, NSCs (1 × 105 in 400 µL culture media) were seeded into the upper chamber of a 24 - well Boyden chamber with an 8 µm pore - size membrane, and tumor cell - conditioned medium (600 µL) was added to the bottom chamber.

No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.

Interestingly, long - term — cultured human epithelial cancer cells in clonal cultures also form holoclones, meroclones, and paraclones, and tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.

Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations of aluminum in the amount of those measured in the human breast are able to transform cultured mammary epithelial cells, allowing them to form tumors and to metastasize.

He had been working at Sun Yat Sen University in Guangzhou on his own projects and told me that he had discovered a method for culturing cancer stem cells from breast tumors.

Evidence - Based Review of Surgical Treatment for Canine Cranial Cruciate Ligament Rupture Beyond Culture: Unraveling the Role of Bacteria in Gastrointestinal Disease Feline Pancreatitis Understanding Intestinal Microbiota - A Role for Probiotics Repair of Oro - Nasal Fistulae Canine Mast Cell Tumors Feline IBD (Inflammatory Bowel Disease): Diets, Bacteria, Diagnosis Addressing Behavioral Welfare of Dogs and Cats at Home and at the Veterinary Clinic Evidence - Based Approach to Management of Chronic Kidney Disease Diagnosis and Management of Feline Hyperthyroidism The Effect of Stress, Fear, and Anxiety on Behavioral Health and Welfare Diagnosis and Management of Feline Diabetes Diagnostic Approach to Lameness MRSA in the Veterinary Environment Canine and Feline Demodicosis Understanding and Working with Reactivity in Dogs Feline Friendly Handling

They will study canine genes of interesl to this pathway in both cOSA tumor specimens and cOSA cell lines in culture.