Sentences with phrase «tumor cells in laboratory»

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

Such resistance may help explain why drugs that eradicate tumor cells in laboratory dishes often fail to eliminate malignancies in the body

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

Not exact matches

Chan's laboratory uses genomic analyses to identify neoantigens — novel peptides found only in tumors that arise from mutations accumulated by cancerous cells.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

The personalized vaccine is made from patients» own immune cells, which are exposed in the laboratory to the contents of the patients» tumor cells, and then injected into the patients to initiate a wider immune response.

The team also compared the animals» responses to the therapy's effects in laboratory cell samples and found that in vitro studies did not predict how well the viral therapy and immune response would fight tumor cells in vivo.

Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

The initial experiments made use of cancer cells that Quiñones - Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistant to chemotherapy and radiation, and capable of creating new tumors.

Frank Ruscetti, who had discovered HTLV - 1 while working in Robert Gallo's Laboratory of Tumor Cell Biology at the NCI in 1980, was Mikovits's primary collaborator.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

Understanding how cancer cells are able to metastasize — migrate from the primary tumor to distant sites in the body — and developing therapies to inhibit this process are the focus of many laboratories around the country.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

In studies of laboratory - grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.

«The results were remarkable, with significant shrinkage in patient - derived tumors,» said Memarzadeh, who also is an associate professor of obstetrics and gynecology and the director of the G.O. Discovery Laboratory at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and associate professor.

In this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cellIn this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cellin both normal and tumor CR laboratory cells.

In the laboratory they showed how morphine can increase proliferation, migration and invasion of tumor cells.

The scientists in Augustin's laboratory consequently pursued preclinical tumor therapy experiments, which were aimed at not just blocking angiogenesis, but to also suppress the production of tumor - promoting growth factors in endothelial cells.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

«Our results suggest that sialidase could sensitize myeloid cells in tumors to previously ineffective STAT3 inhibitors,» said Vinit Kumar, Ph.D., staff scientist in the Gabrilovich laboratory at The Wistar Institute and first author of the study.

As in the laboratory cell samples, there was a rapid degradation of BRD4 in the tumor cells and a powerful anti-leukemia effect, with few noticeable side effects.

Researchers demonstrated that the drugs pemetrexed and gemcitabine killed cells from mouse and human brain tumors, called group 3 medulloblastoma, growing in the laboratory.

Zhang's laboratory now seeks to understand the mechanisms of the tissue - environment influence, opening the possibility that the environment could be altered in a way that fights cancer by preventing tumor cell growth.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

In our laboratory we had the idea of localizing on tumor cells, with specific monoclonal antibodies, molecules, such as Major Histocompatibility Complexe (MHC), loaded with viral peptides, which can activate the T lymphocytes to attack the target tumor cells.

In the past 10 years our laboratory has investigated the role of cell - matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesiIn the past 10 years our laboratory has investigated the role of cell - matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesiin the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesiin vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesiin vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesiin the setting of tumor associated angiogenesis.

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

Results published by the Altieri laboratory demonstrated that these molecules accumulate in mitochondria of tumor cells, where they physically interact with components of the organelle permeability transition as well as with a number of regulators of bioenergetics, including the control of protein production, lipid metabolism and ATP generation.

The Altieri laboratory explores the mechanisms that underlie how tumor cells survive and proliferate in cancer.

Researchers in the laboratory of Mikhail Shapiro, assistant professor of chemical engineering and Heritage Medical Research Institute Investigator, have invented a new method to link magnetic resonance imaging (MRI) signals to gene expression in cells — including tumor cells — in living tissues.

The Altieri laboratory is interested in how tumor cells evade apoptosis — also known as programmed cell death — which is the process that normally causes dysfunctional cells to self - destruct.

In laboratory experiments the researchers mimicked the way SOX9 is stabilized in brain tumor cells and showed how SOX9 turned on 40 to 50 genes in the tumor to make it more resistant to chemotherapy and more prone to spreaIn laboratory experiments the researchers mimicked the way SOX9 is stabilized in brain tumor cells and showed how SOX9 turned on 40 to 50 genes in the tumor to make it more resistant to chemotherapy and more prone to spreain brain tumor cells and showed how SOX9 turned on 40 to 50 genes in the tumor to make it more resistant to chemotherapy and more prone to spreain the tumor to make it more resistant to chemotherapy and more prone to spread.

The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.

The recently discovered protein NUDT5 is now presented as a candidate target for development of breast cancer treatment after being demonstrated to stop breast tumor cell growth in laboratory experiments.

The team is utilizing SU2C's unique «tumor organoid» technology in which an individual patient's tumor cells are grown in the laboratory, creating «mini tumors» which can then be tested to see if a particular treatment is optimal.

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

In laboratory studies, the turmeric (curcumin) herb reduced the growth of cancerous cells and inhibited the growth of tumors in the laboratory test animalIn laboratory studies, the turmeric (curcumin) herb reduced the growth of cancerous cells and inhibited the growth of tumors in the laboratory test animalin the laboratory test animals.

In the laboratory animal study, ursolic acid, the active compound in holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alonIn the laboratory animal study, ursolic acid, the active compound in holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alonin holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alone.

In a laboratory study published in 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellIn a laboratory study published in 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellin 2012 in Oncology Reports, chokeberries caused the death of malignant brain tumor cellin Oncology Reports, chokeberries caused the death of malignant brain tumor cells.

Multiple studies in laboratory's show that curcumin can reduce the growth of tumors, the spreading of cancer, and contribute to overall cancer cell death.

After irradiating the tumor, veterinarians collect a particular type of the dog's white blood cells, known as Natural Killer (NK) cells, then stimulate and grow the cells in a laboratory before injecting them back into the dog's tumor.

Markkanen continues, «For research on breast carcinoma, tumor tissue of dogs is therefore, among other reasons, much better suitable than tissue from rats or cells cultivated in the laboratory.

Re-directed Autologous T cell Therapy for drug resistant or refractory CD20 + B cell lymphoma Overview: In this approach, immune cells (known as T cells) are taken from the peripheral blood, genetically modified in the laboratory to express a receptor that recognizes B cells, and then expanded to produce large numbers of tumor specific T cells outside -LSB-..In this approach, immune cells (known as T cells) are taken from the peripheral blood, genetically modified in the laboratory to express a receptor that recognizes B cells, and then expanded to produce large numbers of tumor specific T cells outside -LSB-..in the laboratory to express a receptor that recognizes B cells, and then expanded to produce large numbers of tumor specific T cells outside -LSB-...]