Sentences with phrase «tumor cells of origin»

The approach helped to discover and nominate Lmx1A as a master regulator transcription factor of Group 4 tumors, which led to the identification of the likely Group 4 tumor cells of origin.

Not exact matches

They found that depending on the cell of origin, mutations in PIK3CA and p53 induced very different types of tumors.

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.

Without the genome sequence of Lacks» healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

One feature of the tumor cells that the researchers were particularly interested in was their sensitivity to cancer drugs, and here too they found a correlation with the cell of origin.

This indicated that the cell of origin also has a direct influence on the characteristics of human tumors,» says Uhrbom.

«We discovered that several important characteristics of the cancer cells could be linked to the tumor's cell of origin.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

Different cell types exhibit characteristic patterns of DNA methylation which enable scientists to draw conclusions about a tumor's cellular origin.

She is studying the cell of origin that is responsible for the highly malignant pediatric brain tumor known as an Atypical Teratoid Rhabdoid Tumor (AT /tumor known as an Atypical Teratoid Rhabdoid Tumor (AT /Tumor (AT / RT).

Research led by a St. Jude scientist has pinpointed likely cells of origin for a common childhood brain tumor, Group 4 medulloblastoma.

The actual cell of origin is different in each type of tumor, and does not have to be atumor stem cell.

The cell of origin also affects tumor susceptibility to treatment.

Cell lineage tracing analysis helped researchers identify early endothelial cells as the cell of origin for the tumor subtCell lineage tracing analysis helped researchers identify early endothelial cells as the cell of origin for the tumor subtcell of origin for the tumor subtype.

Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell - type specificity of chromatin structure.

«Knowing the cell of origin of cancer cells can provide insight into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.

These masses are benign tumors of basal cell origin (meaning they do not metastasize), and they are the most common skin tumors of guinea pigs.

The names of the various skin tumors are assigned according to the type of the cell of origin.

The exact cell of origin of this tumor is unknown.

These, together with the origin or type of tumor, the grade (differentiation or degree with which the tumor cells resemble normal cells) and stage (how large it is and extent of spread) indicate how the cancer will behave (the prognosis).

The tissue of origin is not always clear and granular cell tumors may be of nerve (Schwann cell) origin.

These, together with the origin or type of tumor, the grade (degree of resemblance to normal cells or «differentiation») and stage (how large it is and extent of spread) indicate how the cancer is likely to behave.

Due to their cell of origin, they tend to arise within the ventricular system and can block drainage of CSF, thus a small tumor can cause very severe neurologic signs.

Cutaneous histiocytomas are benign round cell tumors of Langerhans cell origin.