«The big surprise,» Discher said, «is that injected macrophages circulate all around the
body but accumulate only
within the
tumors where they engorge on cancer
cells.»
All patients who received the CTL019 «hunter»
cells experienced a cytokine release syndrome (CRS)
within a few days after receiving their infusions — a key indicator that the engineered
cells have begun proliferating and killing
tumor cells in the
body.
According to recent research, the most common solid
tumors (that is, cancer that occurs as clusters of
cells in or on organs, rather than in liquid form
within the blood or lymphatic system) have up to 66 mutations that influence how the cancer
cells operate — how fast they divide, whether they are susceptible to the signals that would normally cause a
cell to die, when they detach from the main
tumor to colonize another organ in the
body, when and where they attach blood vessels to healthy tissues.