Sentences with phrase «tumor characteristics in»
This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.
https://www.sciencedaily.com/ Not exact matches
«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»
Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.
The cells in such a brain tumor can display very different characteristics, such as varying cell size or number of cell nuclei.
Sharma had developed a new method for studying how tumors with different characteristics respond to different immunotherapies: She would treat patients before their growths were surgically removed, then analyze the tissue in her lab.
Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.
With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.
«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.
Storm, who performs surgery on children with brain tumors, added that, «Better understanding of tumor characteristics, as we found in this research, will help guide our surgical planning and clinical decisions for patients with PLGGs in this current era of target - centric clinical trials and personalized medicine.»
In this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cellIn this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cellin both normal and tumor CR laboratory cells.
In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrencIn their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrencin the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrencin African American patients and appeared to be associated with a greater risk of tumor recurrence.
To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).
These studies revealed that the void's physical characteristics — the type and location of missing bone — were consistent with a fibrous dysplastic neoplasm, a tumor caused by a bone growth disorder, the scientists report online today in PLOS ONE.
«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.
To be able to treat cancer of the central nervous system (CNS) successfully, it is important to have very precise knowledge about the molecular characteristics of the tumors in order to «give them the right name.»
Lloyd A. Greene and Arthur S. Tischler of the Harvard Medical School demonstrated in 1977 that cells of the line designated PC12 (which are derived from a rat tumor) respond to NGF by acquiring properties characteristic of sympathetic neurons.
Douglas Hanahan and Robert Weinberg publish an update of their seminal review, Hallmarks of Cancer, adding to the list of cancer characteristics the ability of tumors to evade the immune system and emphasizing immune system - induced inflammation as an enabling characteristic in cancer development.
About 1,000 patients whose tumor characteristics most closely match one of the 20 or so gene - targeting drugs offered in the study will be put into groups of about 30 patients to get that drug.
Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.
The researchers looked at several factors that might explain this racial difference, such as whether there were differences in tumor characteristics between black patients and white patients, or differences in a family history of breast cancer — both factors that a doctor must consider before deciding whether a genetic test will likely benefit a particular patient.
Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.
More recently, scientists including Benjamin Spike, a co-first author on the current work and post-doctoral fellow in the Wahl lab, have discovered that tumors often contain cells with stem cell characteristics revealed by their genetic signatures.
Known as tumor - initiating cells with stem like properties these cells have many characteristics in common with normal stem cells in that they are self - replicating and capable of giving rise to populations of differentiated cells.
«Cells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stewart.
Research Paper Shared liver - like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors Jun Cheng, Xuekun Song, Lu Ao, Rou Chen, Meirong Chi, You Guo, Jiahui Zhang, Hongdong Li, Wenyuan Zhao, Zheng Guo, Xianlong Wang J. Cancer 2018; 9 (8): 1500 - 1505.
In this trial, we have the opportunity to treat every patient as unique, and to tailor each one's therapy to each one's tumor characteristics.»
Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??
CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.
The NAVBO Meritorious Awards Committee and Council is pleased to announce the selection of Rakesh K. Jain, Ph.D., as the 2018 recipient of the Earl P. Benditt Award, in recognition of his numerous contributions to our understanding of the unique characteristics of tumor vasculature.
«While chemotherapy treats the tumor directly, immunotherapy treats the immune system, which results in distinct clinical characteristics.
CSCs are a minority group of cells (usually about 1 in 10000) within solid tumors of hematological cancers, which possess similar characteristics to normal stem cells.
Salt and cancer Balancing an iodine deficiency; 3 types of people In the 1st case of balancing an iodine deficiency Possible allergic reactions to taking iodine Lugol's iodine / iodide in Solution Dosage My use of the Iodoral 12.5 mg iodine / iodide tablet form Monitoring for activation of iodine Maintenance dose of iodine supplementation My iodine is not activating «person 2» Niacin and its unique characteristics Niacin, bleeding and notes of caution My basal cell temperature is normal / possible infection «person 3» Iodine Spot Loading Test Recapping the 3 types of people with iodine deficiency Tumors and topical application of iodine Cellect / Budwig protocol; step 4 addition of the nutritional product Cellect including Cellect / Budwig notations through observatioIn the 1st case of balancing an iodine deficiency Possible allergic reactions to taking iodine Lugol's iodine / iodide in Solution Dosage My use of the Iodoral 12.5 mg iodine / iodide tablet form Monitoring for activation of iodine Maintenance dose of iodine supplementation My iodine is not activating «person 2» Niacin and its unique characteristics Niacin, bleeding and notes of caution My basal cell temperature is normal / possible infection «person 3» Iodine Spot Loading Test Recapping the 3 types of people with iodine deficiency Tumors and topical application of iodine Cellect / Budwig protocol; step 4 addition of the nutritional product Cellect including Cellect / Budwig notations through observatioin Solution Dosage My use of the Iodoral 12.5 mg iodine / iodide tablet form Monitoring for activation of iodine Maintenance dose of iodine supplementation My iodine is not activating «person 2» Niacin and its unique characteristics Niacin, bleeding and notes of caution My basal cell temperature is normal / possible infection «person 3» Iodine Spot Loading Test Recapping the 3 types of people with iodine deficiency Tumors and topical application of iodine Cellect / Budwig protocol; step 4 addition of the nutritional product Cellect including Cellect / Budwig notations through observations
It must be kept in mind that CT or MRI characteristics of a tumor alone are not enough to make a definitive diagnosis.
Radiographically, the tumor contains nodular or stippled areas of mineralization, resulting in a characteristic «popcorn ball» appearance.