Sentences with phrase «tumor cytotoxicity»
The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].
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In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivo.
Similarly, antigen - specific CD4 + CD25 + regulatory T cells also suppress tumor - specific CD8 T cell cytotoxicity although this mechanism relies on TGF - β secretion by regulatory cells 196, 197.
In cytotoxicity assays employing PPAM, we found no significant differences of IC50 values between SCLC tumor cells, SCLC CTC lines which express the Wnt pathway and normal cells such as HEK293 (data not shown).
They found that decreased presence of lymphatic vessels and reduced immune cytotoxicity were more strongly associated with the metastatic process than tumor - intrinsic factors such as chromosomal instability or cancer - associated mutations.
Though this exploitation of biochemical and cellular pathways, the Gelipo - TRAIL - Dox combo accumulated more than the controls in the affected tumor tissue and had a greater cytotoxicity.