Sentences with phrase «tumor development as»

It may help protect against tumor development as well as act as a block enzymes associated with cancer, according to an article in Cancer Letters journal.

A review of the somewhat limited data from these and earlier studies (1) indicated that inhibition of tumor development as a result of marginal intakes of various proteins could be abolished by supplementation with the respective limiting amino acid for each protein... [O] ur results suggest that the enhancement of focus development by lysine supplementation of gluten is due to a general improvement in dietary protein quality and not to any particular metabolic effect peculiar to lysine.

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

Interestingly, the chimeric mice can be directly used to monitor tumor development as they contain the same genetic alterations as the original GEMM including the altered target gene expression.

Not exact matches

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

The findings support further development of the drug as a novel treatment for brain tumors.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

As not all cases of Barrett esophagus become malignant, it is important for the treating physician to know whether there are reliable indicators (so - called biomarkers) which allow the estimation of a tumor development in the still benign tissue.

The researchers used an example to demonstrate the mechanism: They identified the transcription factor STAT3, which regulates inflammatory processes and can promote tumor development, as a prominent target protein of one peroxiredoxin.

How cell division occurs and is coordinated with organismal development is a subject of intense research interest, as is how this process malfunctions in the development of tumors.

This transformation recognizes that the immune inflammatory state serves as a key mediator of the middle stages of tumor development.

«Because gastric secretions are activated by the intake of food via the stomach, there are no signs of being abnormal before birth, but by restoring normal gastric acid balance as soon as possible afterwards, we can eliminate the conditions that lead to the development of tumors.»

Hockfield came to MIT from Yale University, where she spent 20 years studying brain development and brain tumors and served as provost.

Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

Blood vessel development is critical for the growth of any solid tumor, such as breast, colon or lung cancer.

«To answer these questions, one has to divide cancers into two groups: solid tumors that require the development of a blood supply to metastasize and enlarge, and soft tumors that may have circulating cells, as in leukemias.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

When the pathway becomes dysregulated — as in during genetic mutation — it helps drive the development of tumors.

Kruger summarizes the research results as follows: «The early metastasis of tumor cells usually constitutes the critical step in cancer development.

The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI / SNF - MYC / MAX network is essential for lung cancer development.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, known as Stk11, additionally influenced the development of BPH.

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

More importantly, Zhang and his team for the first time found that treating the pancreatic tumor cells with MIR506 induced autophagy, a process that occurs as a normal and controlled part of an organism's growth or development and that could promote cancer cell death.

Douglas Hanahan and Robert Weinberg publish an update of their seminal review, Hallmarks of Cancer, adding to the list of cancer characteristics the ability of tumors to evade the immune system and emphasizing immune system - induced inflammation as an enabling characteristic in cancer development.

As this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presentAs this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presentas to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presents.

One group of small, non-coding RNA molecules could serve as a marker to improve cancer staging and may also be able to convert some advanced tumors to more treatable stages, report a University of Chicago - based research team in the April 1, 2008, issue of the journal Genes & Development.

Purpose: The development of the UNC Immuno - Oncology Patient Centered Translational Research (IMPACT) Biorepository involves the collection of tumor tissue and blood, as well as data (e.g., demographic, clinical, questionnaire) from patients attending Oncology Clinics at UNC Hospital and undergoing immune therapy through participation in a Merck IT trial at UNC.

Scientists could also use the printed tissue constructs to shed light on activities of living tissue that require complex architecture, such as wound healing, blood vessel growth, or tumor development.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of canceAs a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of canceas this would fuel the development of cancer.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Fishman, in particular, wanted to advance his studies in oncodevelopmental biology, exploiting proteins involved in embryonic development as tumor markers.

It will also be used to measure the impact of various preventive therapies, such as green tea, on tumor development.

Over the last 3 years, the partnership between the Salk Institute and Ipsen has delivered significant scientific advances in the cancer field such as the development of biological models mimicking human cancerous processes as well as identification of specific cells driving tumor growth.

I will investigate whether the enteric nervous system, an neglected member of the tumor - microenvironment, plays a role in the development of colorectal cancer and can be used as a potential therapeutic target.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

For example, the discovery of cancer - causing genetic and epigenetic changes in tumors has enabled the development of therapies that target these changes as well as diagnostic tests that identify patients who may benefit from these therapies.

The efficient compaction of DNA during cellular division ensures equal distribution of DNA into daughter cells and prevents aneuploidy, which has been implicated as a major driver of tumor development.

My first research efforts as an independent scientist were aimed at the development of high - sensitivity MR tracers (dubbed hyperpolarized agents) to map perfusion in healthy tissues and tumors.

The recently discovered protein NUDT5 is now presented as a candidate target for development of breast cancer treatment after being demonstrated to stop breast tumor cell growth in laboratory experiments.

Spheroids serve as models for the development of healthy tissues and their maintenance in the living organism but also as models for tumor growth (Pampaloni et al. 2007).

Neoantigens — called so because they are newly formed during cancer development — may represent ideal immunotherapy targets as they are solely expressed on tumor cells.

As evidenced by this boy's experience, one of the biggest potential problems with stem cell therapy is the development of tumors.

The challenge takes on even more urgency with recent developments, including a federal administration now more open to exploring the potential of stem cells, the recent FDA approval of a human trial involving embryonic stem cells, as well as the reported case of a young boy who developed a brain tumor four years after receiving a stem - cell treatment for a rare genetic disorder.