Sentences with phrase «tumor development in»

And lab experiments have shown that estrogen may inhibit tumor development in the colon by affecting cell growth, or by lowering levels of a cancer - linked hormone called IGF - 1.

What many pet owners do not know is that the incidence of mammary tumor development in dogs is higher yet, with one in four unspayed female dogs affected.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

Spontaneous mammary tumor development in C3H / HeJ mice was reduced.

We also unraveled the role of PHD2 in different cancer cells during tumor development in mice.

As few as 100 PC3 cells initiated tumor development in one of the eight injections and at ≥ 10,000 cells most of the injections of either PC3 or PC3 - GFP cells developed tumors (Table 1).

Three holoclones (i.e., P3C4, P1E2, and P1H8), harvested around 6 to 8 weeks after plating, when injected at 1,000 or 10,000 cells, all initiated 80 % to 100 % tumor development in NOD / SCID mice in 47 to 75 days (Table 1; Fig. 3A).

As shown in Table 1, both PC3 and PC3 - GFP cells initiated cell number — dependent tumor development in NOD / SCID mice.

When tertiary tumor transplantation experiments were carried out with P3C4 and P1E2 secondary tumor — derived cells, 1,000 cells again reinitiated tumor development in 90 % of injections (Table 1; Fig. 3C).

We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.

In 2016, another Berkeley Lab group found a potential new biomarker for early stages of tumor development in a wide variety of cancers.

These signaling molecules may also play a role in tumor development in other organs, and are being evaluated in melanoma and other tumor types.

The investigators also identified alteration in NTRK genes that drove tumor development in young HGG patients whose tumors developed outside the brainstem.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.

«The macrophage is migrating into a site and doing what we want it to do rather than driving tumor development in a normal way,» Lewis says.

Sometimes oncogenes manage to initiate tumor development in the presence of p53, but, even then, the tumor suppressor doesn't give up and focuses its efforts instead on limiting the tumor's ability to invade and metastasize.

Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.

As not all cases of Barrett esophagus become malignant, it is important for the treating physician to know whether there are reliable indicators (so - called biomarkers) which allow the estimation of a tumor development in the still benign tissue.

This treatment prevented the formation of polyps, showing that bacteria are essential for early tumor development in this model.

Not exact matches

Her discovery of radium lead to the development of using X-rays in medicine, and Curie was at the forefront for cancer research, directing the first studies that used radiation to treat tumors.

Frustrated with the lack of investment in research and drug development devoted to pediatric brain tumor gliomas, the Kamens decided to take action and launch their foundation.

Prior to the development of a fully functioning nervous system, and the activation of said system, a human embryo is «alive» in the same sense a tumor is «alive»: the individual cells that make it up are alive, but there is no higher - level functionality.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

Because a majority of tumors exhibit phosphorylation changes at some point in their development, his lab looked specifically at protein phosphorylation in vesicles.

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

Scientists at the Rosalind Franklin University of Medicine and Science in Chicago found a «remarkable similarity» between the cells that support the growth and development in placentas and in tumors.

The findings, which were demonstrated in several major subtypes of melanoma tumors (including BRAF and NRAS melanoma), could lead to drug development strategies that suppress the development of drug resistance.

Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

Moreover, experiments on an ovarian cancer murine model that investigated the effects of orally administered ONA resulted in longer lifespans and inhibited ovarian cancer tumor development.

This happens particularly often during the stage of embryonic development, but it can also occur in tumors when they form metastases.

Dr. Sergio Lira and his team at the Icahn School of Medicine at Mount Sinai, New York, asked if gut microbes have a hand in tumor development.

After identifying FAK's role in tumor development, François started looking for ways to get it in check.

Our long - term goal is to translate this technology into clinical investigation of the pathological implication of exosomes in tumor development.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

Along with finding that the tumor suppressor protein SIRT6 is inactive in around 30 percent of cases of pancreatic ductal adenocarcinoma (PDAC), the team identified the precise pathway by which SIRT6 suppresses PDAC development, a mechanism different from the way it suppresses colorectal cancer.

And in at least a few lab - reared fish, UV can initiate the development of melanoma (especially among hybrids which inherit a tumor - promoting gene from one parent but no accompanying tumor - suppressor gene from the other).

Although normal inflammation plays an important role in helping to fight off infections, there is mounting evidence that chronic inflammation is linked to increased risk of tumor development.

The opposing functions of TAMs in the development of tumors arise the question whether there are specific factors within the micro-environment of the tumor which dictate the phenotype of these TAMs.

Next steps for this research will see new refinements in the endomicroscope instrument and development of new tumor cell stains and probes that light up the tumor cells to an even greater degree.

EMT is crucial for normal embryonic development, but also operates in wound healing, and when abnormally switched on, can enable the spread of tumor cells.

When cancer cells start dividing rapidly to form tumors, these cells are actually reverting to an earlier time in their development when they were supposed to divide rapidly.

The work demonstrates that BRAF - mutated melanoma requires autophagy for tumor development and blocking autophagy could have therapeutic value, particularly in combination with BRAF inhibition.

The study, «The nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.