Sentences with phrase «tumor development using»

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

Not exact matches

Her discovery of radium lead to the development of using X-rays in medicine, and Curie was at the forefront for cancer research, directing the first studies that used radiation to treat tumors.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

The researchers used an example to demonstrate the mechanism: They identified the transcription factor STAT3, which regulates inflammatory processes and can promote tumor development, as a prominent target protein of one peroxiredoxin.

Based on their results, Lu and her colleagues argue that the best strategy in such cases might be to use drug combinations that target multiple, parallel pathways involved in tumor development and maintenance.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

This innovative approach — using high - intensity sequencing to detect cancer from circulating tumor DNA in the bloodstream — heralds the development of future tests for early cancer detection.

While circulating tumor DNA tests targeting a smaller set of cancer genes are already available for use in routine practice to guide care, by covering a much larger number of cancer genes, this high - intensity sequencing approach may enable development of future tests for early detection of cancer.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

A research team led by Kerstin Lindblad - Toh at Uppsala University / SciLifeLab has used genetic analyses of 25 different dog breeds to identify genes that could have a role in the development of brain tumors.

Rose is currently awaiting results from a new round of mice in development using newer tumor cells.

Scientists could also use the printed tissue constructs to shed light on activities of living tissue that require complex architecture, such as wound healing, blood vessel growth, or tumor development.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

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It will also be used to measure the impact of various preventive therapies, such as green tea, on tumor development.

I will investigate whether the enteric nervous system, an neglected member of the tumor - microenvironment, plays a role in the development of colorectal cancer and can be used as a potential therapeutic target.

Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of lung cancer; collaboration between medical and materials science researchers to develop treatments for various types of leukemia using nanotechnology to target only cancer cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to tumor development.

Interestingly, the chimeric mice can be directly used to monitor tumor development as they contain the same genetic alterations as the original GEMM including the altered target gene expression.

This Institute is conducting ground - breaking research in the area of tumor biology and the development of cancer biomarkers using genomic and proteomic technologies in the hands of world - class scientists.

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

Most of these CSCs have been identified using surface markers that identify their corresponding normal tissue stem and progenitor cells, thus reinforcing the resemblance of tumor development to normal organogenesis.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Finally, analysis of tumors from clinical trials and cell line models will allow discovery of mechanisms of sensitivity and resistance to AR and PI3K inhibitors, as well as biomarkers that can be used in the development of new treatment regimens and selection of patients for future trials.

The stage of B cell development represented by PEL, how this stage relates to tumor pathology, and how this information may be used to treat the disease are largely unknown.

Studies are focused on the pre-clinical development and design of more effective therapeutic approaches to cancer using mouse tumor model systems.

The most famous, oldest, and most commonly used immortal cell line, dubbed HeLa, originated in a tumor sample taken from an African - American woman, Henrietta Lacks, who is the subject of the recent book The Immortal Life of Henrietta Lacks.9 The tumor cells, harvested at Johns Hopkins Hospital, gave rise to the eponymous HeLa cell line which researchers have used continuously since her death in 1951 for numerous experiments, including Jonas Salk's development of the polio vaccine.

This tremendous study suggested that pre-cancerous lesions can be used to predict the development of true tumors with 90 - 98 % accuracy.