Sentences with phrase «tumor environment»

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

«New synthetic tumor environments make cancer research more realistic.»

Beyond the fundamental science of finding and understanding these cancer - spreading cells, he also sees engineered tumor environments as having therapeutic applications in personalized medicine.

Cells that are able to shut down the activity of miR - 483 and miR - 551, the researchers found, increase production of an enzyme known as CKB, which can help the cells convert compounds found abundantly in the liver tumor environment into an energy source.

We now know how we can switch an immunosuppressive tumor environment to an immunosupportive one, enabling the action of NK cells.

Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.

The proposed project therefore aims at determining the interplay between the heterogeneous tumor cells and the associated tumor environment.

The DNRII expressed by the T cells allowed the cells to resist the hostile tumor environment and kill the tumor cells without lymphodepleting chemotherapy before infusion.

They found that cancer stem cells seemed to appear in the highest numbers along the edges of the engineered tumor environments, particularly where there were corners and convex curves.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

«But what we're not sure of yet is whether certain bacteria are found near breast tumors because they cause breast cancer or because they just thrive in the tumor environment.»

«For the first time, we proved that a type of immunosuppressive cells within the tumor environment play a major role in determining the impact of immunotherapies,» Castro says.

Alternate reading frame protein (ARF) complexes with mouse double minute 2 homolog 2 (MDM2), an E3 ubiquitin ligase that regulates the stability of p53 and therefore suppressing tumor growth, it is also involved in the immune response, by modulating the tumor environment [46].

Through her CLIP Grant, she is analyzing patient samples to determine how Poly ICLC (a TLR agonist) affects the tumor environment and immune responses against specific mutations, to identify how Poly ICLC could complement existing immunotherapies.

CRI associate director Glenn Dranoff, M.D., and his colleagues at the Dana - Farber Cancer Institute in Boston presented intriguing results from their lab showing that mutations in EGFR lead to increased activation of the PD - 1 pathway in the tumor environment.

The mechanical properties of tumors and the tumor environment provide important information for the progression and characterization of cancer.

Identifying and exploiting a novel mechanism that may disrupt this process by inhibiting the interactions between tumor cells and cells in the tumor environment will speed clinical investigations, and ultimately lead to improved outcomes for dogs with this devastating disease.

Our data continue to clarify the interactions stemming from inflammation in the tumor environment with regard to cell autonomous growth and survival, reinforcement of traits associated with metastasis, and interactions with other constituents of the microenvironment.