Sentences with phrase «tumor epigenome»
He also plans to leverage the latest sequencing technologies to understand how complex rearrangements impact the tumor epigenome and perturb cancer genome structure over time.
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His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.
Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.
«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»
Specifically, they analyzed the tumors» epigenome, an array of molecules that covers the surface of DNA and helps regulate gene activity, acting like a control switch to decide which genes are active or inactive in the cell.