Sentences with phrase «tumor evolution»
"Tumor evolution" refers to the changes that occur in a tumor over time. Just like living organisms, tumors can change and develop new characteristics as they grow. This term is used to describe the process in which a tumor acquires new genetic mutations or alters existing ones, leading to its progression and potentially making it harder to treat. Full definition
This finding has the potential to improve real - time monitoring of tumor evolution during treatment, You said.
sciencedaily.com
But I think the [tumor evolution] study was a bit of a wake - up call.
Tracking sequence changes over time could also provide a kind of early warning system to identify the emergence of an aggressive form of the cancer by providing a real - time window into tumor evolution.
In January, TGI and its collaborators published three Nature papers that came online the same day: one on the genetic basis of an aggressive pediatric leukemia, another on genomic and epigenetic analyses of childhood retinoblastoma, and a third on tumor evolution in relapsed AML.
His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.
In collaboration with the University College London (UCL) Cancer Trials Centre and the UCL Cancer Institute, Swanton's research group will be following about 850 patients with NSCLC from diagnosis to death as part of a clinical trial to understand tumor evolution.
Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.
I. Develop a 3D cancer atlas Create dynamic 3D maps of human tumor evolution to document the genetic lesions and cellular interactions of each tumor as it evolves from a precancerous lesion to advanced cancer.
Swanton says he hopes the findings will eventually lead to the development of a «rule book» on ccRCC tumor evolution that will allow clinicians to quickly identify which subtype a patient has and then provide an accurate prognosis.
Using a systems biology approach, scientists uncover important general principles of glioblastoma tumor evolution.
Swanton's goal is to map tumor evolution and adaptation over space and time.
Tumor evolution in two patients with basal - like breast cancer: A retrospective genomics study of multiple metastases.
«These results provide an unprecedented window into the cellular dynamics of tumor evolution and suggest that interactions between subpopulations of tumor cell types contribute to metastatic progression from initial tumors,» Stanger said.
Navin's study supports the «bursts» model and demonstrates the majority of CNAs are acquired at the earliest stages of tumor evolution.
The Tumor Evolution and Progression, Cancer Immunology, and Precision Prevention and Early Detection working groups all proposed generation of human atlases of cancer.
The Pediatric Cancer and Tumor Evolution and Progression working groups jointly recommended efforts to identify new therapeutic targets to overcome cancer resistance.
Four other AML cases in this study were consistent with this model of tumor evolution.
Current projects include quantitative models of the tumor microenvironment, the adaptive immune repertoire, and tumor evolution.
Penn animal study has implications for better drug design, «unprecedented window» into tumor evolution