Sentences with phrase «tumor evolution in»

In January, TGI and its collaborators published three Nature papers that came online the same day: one on the genetic basis of an aggressive pediatric leukemia, another on genomic and epigenetic analyses of childhood retinoblastoma, and a third on tumor evolution in relapsed AML.

Not exact matches

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

«This was a very difficult study to do, but it allowed us to take a snapshot of both the primary tumor, and the tumor after it had spread, in order to trace its evolution,» said the study's first author Marni Siegel, a graduate student in the UNC MD / PhD program.

In collaboration with the University College London (UCL) Cancer Trials Centre and the UCL Cancer Institute, Swanton's research group will be following about 850 patients with NSCLC from diagnosis to death as part of a clinical trial to understand tumor evolution.

«Another model is punctuated evolution in which CNAs are acquired in short bursts of crisis, followed by stable clonal expansion that form the tumor mass.

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

Charles Swanton, a cancer geneticist at the Francis Crick Institute in London, and colleagues analyzed 1,206 clear - cell renal cell carcinoma (ccRCC) tumor samples from 101 patients as part of the Tracking Cancer Evolution through therapy (TRACERx) program.

The branched, Darwinian subtype — «if you like, the microevolutionary tumors,» says Swanton — acquire chromosomal complexity when they lose alleles in chromosomes 9 and 14 late in their evolution.

In a way, tumor cells are acting somewhat Nietzschean, blindly managing their own cheap oakley evolution according to the principle â $ œWhatever doesnâ $ ™ t kill me makes me stronger.â $

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.

«With 100 million mutations, each capable of altering a protein in some way, there is a high probability that a significant minority of tumor cells will survive, even after aggressive treatment,» said study director Chung - I Wu, PhD, professor of ecology and evolution at the University of Chicago.

Most of the 8,800 annual deaths in the United States are of patients who relapse with a tumor that has undergone clonal evolution at the cytogenetic level.

Tumor heterogeneity in solid tumor cancers impacts clonal evolution and patient outcTumor heterogeneity in solid tumor cancers impacts clonal evolution and patient outctumor cancers impacts clonal evolution and patient outcomes.

DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Cellular heterogeneity in solid tumor cancers impacts clonal evolution and patient outcomes.

The loss of HLA often occurred relatively late in the tumors» evolution and resulted in an expansion of neoantigens within the tumors, predicted to bind to the lost HLA allele.

Revealed that the loss of the human leukocyte antigen (HLA) locus in lung cancers is a way these tumors evade the immune system and allow mutation expansion and branched evolution within tumor cells

The application of subclonal reconstruction methods is providing key insights into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between cellular populations, and characterizing the mechanisms of therapy resistance, spread, and metastasis.

Nowell went on to study chromosomal changes in other tumors, and this led him to advance the theory of the clonal evolution of tumor progression.

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