Sentences with phrase «tumor gene mapping»

Not exact matches

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

Based on how the genes fit within the original, mapped profile, they can predict with a high accuracy if a particular patient will develop metastatic tumors.

In four tumors, the vector mapped to a section of chromosome 12 and turned on several genes implicated in cancer, the team reports tomorrow in Science.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

That genetic map led to key insights, such as the link between glioblastoma, the deadliest type of brain tumor, and a gene called BEX1.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).