Sentences with phrase «tumor genes affected»

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

Not exact matches

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

These rearrangements affected several known and suspected oncogenes and tumor suppressor genes, including Notch1, Pten, Ikzf1, Jak1, Phlda1, Trat1, and Agpat9.

«We found polyploidy in liver cells did not strongly affect the activity of some oncogenes, but it did protect against the loss of tumor suppressor genes.

They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.

«This enabled us to study how genes and the tumor microenvironment — not the tumor itself — affect tumor growth.»

At the time, it was thought that this gene fusion was limited to a fraction of brain tumors, affecting about 300 patients in the U.S. per year.

We observed an average of 14.5 «tier 1» (coding) mutations per tumor in the 24 WGS cases; on average, ~ 3 of these affected recurrently mutated genes in M1 tumors, and ~ 2 affected recurrently mutated genes in M3 tumors.

JJ Miranda, PhD, reported that certain drugs affect genes in tumor cells infected with the Epstein - Barr Virus.

In a study published in the journal Biochemical and Biophysical Research Communications, a team led by Miranda examined how certain drugs affect genes in EBV - infected tumor cells.

We are also interested in the interplay of Eph receptor mutations with mutations affecting well - established oncogenes and tumor suppressor genes.

Both mutations affect the function of CDKN2A, a tumor suppressor gene associated with melanoma in humans.

Interestingly, BRCA1 is not a haploid - insufficient tumor suppressor gene; therefore monoallelic deletion may not affect its function or affect tumorigenesis of those breast cancers bearing deletions.