Sentences with phrase «tumor genes associated»

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Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

In addition, 422 genes, and key cancer - associated signaling pathways, were progressively expressed in airways, with a more intense presence closer to the tumor and tapering at further distances.

The software allowed them to cluster genes into groups associated with specific molecular processes and see which processes in tumors and blood cells were associated with each other.

«Even though Foxo1 is a tumor suppressor gene, paradoxically its activity is associated with lymphomas,» said Kurosaki.

• People with paragangliomas and those diagnosed with metastatic tumors should be tested for specific gene mutations associated with those conditions;

The study further suggests that NSAIDs such as aspirin, ibuprofen and naproxen have a particularly advantageous effect when taken after diagnosis by colorectal, or CRC, patients without tumor mutation in the KRAS gene (KRAS wild - type tumors): The study shows that NSAID use by this group is associated with a survival benefit of 40 percent.

Analysis of genomic, epigenetic, and RNA sequencing data revealed that the combinations of mutations that lowered the levels of functioning BRCA1 and BRCA2 RNA — genes that produce the breast cancer tumor suppressor proteins — were associated with significantly better survival outcomes.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Atlas.

The researchers found what they refer to as the mastermind fusion gene — the first fusion gene associated with this type of tumor.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, known as Stk11, additionally influenced the development of BPH.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.

Dr. Eng and team create scoring system to facilitate identifying individuals to be referred to PTEN gene testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers.

Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

Covering a combination of oncogenes and tumor suppressor genes, this panel is designed to cover some of the most commonly mutated genes associate with AML.

The results showed that the mutational spectrum of these genes in PTCL - NOS was similar to that in B - cell lymphoma, in which predominantly missense mutations were found.17, 18 Importantly, our study provided clinical evidence that histone modifier gene mutations, particularly those involved in histone methylation and acetylation, are significantly associated with tumor chemoresistance and disease progression of PTCL - NOS.

Furthermore, our data from hESC - derived NSCs indicate that reprogramming can be achieved without ectopic expression of the tumor - associated genes, c - Myc and Klf4.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].

Radiation - associated breast tumors display a distinct gene expression profile.

Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Both mutations affect the function of CDKN2A, a tumor suppressor gene associated with melanoma in humans.

Patients whose tumors had a gene - expression signature associated with poor survival lived for a period that was 23 percent shorter than patients whose tumors did not have such a signature.

CBX2 overexpression in breast tumors was associated with the upregulation of genes involved in cell cycle progression and is associated with poorer 5 - year survival.

Collectively these tools provided a robust means to interrogate tumor specimens for changes to the genome, which lead to identification of genomic regions and genes associated with cancer.