Sentences with phrase «tumor genomes»
The phrase "tumor genomes" refers to the complete set of genetic material or DNA found in a tumor. It includes all the genetic instructions that contribute to the growth, development, and characteristics of the tumor. By studying tumor genomes, scientists can learn about the genetic changes that occur in a tumor, which can help in understanding the causes of cancer and developing targeted treatment strategies. Full definition
The plan is to scale up to collecting whole - tumor genome sequence data from 3,000 to 4,000 patients annually.
sciencemag.org
Canine tumor genome mapping is a critical step in cancer research.
Last and most difficult to characterize are the sub-microscopic structural changes — insertions, deletions, inversions, translocations, duplications, etc. — that often occur in tumor genomes.
The Blue Buffalo Foundation and Animal Cancer Foundation (ACF) have partnered to embark on the Canine Cancer Genome Project to map tumor genomes in the most common canine cancers.
RAS pathway mutations were not the only changes that distinguished the normal and embryonal tumor genomes.
Only when we functionalize the entire network can we begin to treat individual patients with rational drug combinations based on their unique tumor genome — the promise of personalized medicine.
We've partnered with the Animal Cancer Foundation to initiate the Canine Cancer Genome Project, where researchers will map common canine tumor genomes to unlock crucial information that can benefit both pets and humans with the same disease.
The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome - sequencing efforts and getting the government to cover the costs of genomic tumor profiling.
Unlike previous studies, which tracked lymphoma progression by monitoring the sequence of just one cancer - associated protein, CAPP - Seq can identify a much larger range of mutations in the tumor genome.
The researchers analyzed specific chemical tags in the tumor genomes called DNA methylations.
The authors note that «these observations emphasize the importance of integrating RNA - seq data with tumor genomes,» although this claim would have been far better supported if one did not have to dig through a massive / disorganized Excel file for most of the RNA - seq data.
Next - gen sequencing of tumor genomes was relatively new, and the potential payoff was huge.
In recent years DNA - and RNA - based surveys of tumor genome and expression profiling have produced a plethora of leads on genes with clinical significance.
Over the next three years, we will sequence the tumor genomes of 600 pediatric cancer cases to characterize the inherited and acquired genetic changes that underlie cancer in children.
In tumor genome processing, we identify discrete coverage levels based on the distribution of the observed normalized coverage levels in the tumor genome.
Genome pairs consist of a tumor genome with a matched normal, while genome trios consist of two tumor genomes from the same patient along with the matched normal genome for those two tumors.
In less than a year, the number of Illumina runs required to sequence a tumor genome dropped by over 80 %, from 98 runs in AML1 to just 16.5 runs in AML2.
«The proprietary NantOmics Cancer Genome Browser enables clinicians for the first time to investigate a tumor genome from the full three billion bases down to the single - base level in real - time, thanks to the power of the NantOmics supercomputing infrastructure,» said Patrick Soon - Shiong, M.D., founder and CEO of NantHealth.
The Canine Cancer Genome Project's goal is to map the tumor genomes of the most common canine cancers.
The CCGP project seeks to map the tumor genomes of the most common canine cancers, a missing piece of information cancer researchers need to expedite research to benefit pets and people.