Sentences with phrase «tumor immune tolerance»
Using infectious organisms to break tumor immune tolerance may be an excellent therapeutic option for treating cancer in the future.
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Different classes of MHC molecules exist and are involved in immunity against pathogens and tumor cells as well as the formation of immune tolerance to self - antigens.
In the new study, scientists built upon previous discoveries that a safe, non-reproducing vaccine strain of T. gondii could cure mice of several types of solid tumors, and identified which parasite proteins and which immunological pathways are required to break immune tolerance.
Currently, the use of the bacterium Listeria monocytogenes to break the immune tolerance of pancreatic tumors is being explored in clinical trials and T. gondii may be similarly useful.
One promising strategy in the fight against cancer is to use the body's own immune system to remove tumor cells, but due to a phenomenon called immune tolerance, the immune system has a difficult time identifying which cells to attack.
When the tumor - fighting T cells are kept in check by inhibitory regulatory T cells, scientists speak of «peripheral immune tolerance.»
«New key regulator of acquisition of immune tolerance to tumor cells in cancer patients.»
Interestingly, this state of immune tolerance is similar to what happens during pregnancy, and, more specifically, it's been found that the body's response to a tumor is very similar to its response to embryonic tissues.
His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.
IDO1 has been implicated in immune modulation through its ability to limit T cell function and engage mechanisms of immune tolerance, and as such preventing tumor rejection.