Sentences with phrase «tumor immunosuppression»

Toward this end, the company is leveraging unexploited insights in immunology to discover novel agents that combat cancer by reversing tumor immunosuppression.

Not exact matches

Although changes in treatment methodology still have to be studied, Dr. Cripe believes it may be that the timing of various treatments is what matters, and that perhaps initially suppressing immunity could allow the virus to infect a large number of tumor cells before relieving the immunosuppression to allow the body's own T cells to fight off the tumor.

It suggests that immunosuppression prevails in tumors prior to vaccination.

We want to understand how to use innate immune cells to reverse immunosuppression in the tumor microenvironment.

Bavituximab's presumed mode of action is to block immunosuppression while activating a tumor - killing T - cell immune response.

iTeos uses a platform of in vitro and ex vivo screening assays to reproduce immunosuppression induced by different components of the tumor microenvironment.

PD - 1 is a receptor present on activated T cells, which mediates immunosuppression primarily in peripheral tissues, where PD - 1 ligands, PD - L1 and PD - L2 share an immunosuppressive activity and may be produced by either tumor cells or stromal / tumor - infiltrating immune cells.

To date, they have shown that BiTEs are: (1) highly - specific molecules that greatly reduce the risk of toxicity; (2) have the ability to penetrate the blood - brain barrier and accumulate in intracerebral tumors; and (3) may potentially overcome multiple mechanisms of immunosuppression present in patients with glioblastoma.

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

Any factor or disease that causes immunosuppression increases the risk of tumors occurring in your pet.