Sentences with phrase «tumor initiation»

Many cancers are still difficult to treat and development of drugs exploiting new pathways and mechanisms involved in tumor initiation and malignant growth is of high priority [1].

Any deviation in these processes could lead to cells that do not have the proper number of chromosomes, which could accelerate tumor initiation and progression.

«In conclusion,» Nakano and fellow researchers wrote, «the FOXD1 - ALDH1A3 axis is critical for tumor initiation in mesenchymal GSCs, therefore providing possible new molecular targets for the treatment of GBM and other ALDH1 - activated cancers.»

Mebendazole can be administered with the non-steroidal anti-inflammatory drug sulindac for prevention of tumor initiation in a colon cancer model [33].

Huang YY, Dai L, Gaines D, Droz - Rosario R, Lu H, Liu J, Shen Z. BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression.

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

Once the tumors are established in the mice, the researchers can introduce additional mutations at any time, allowing them to study the influence of each mutation on tumor initiation, progression, and metastasis.

«New mechanism that regulates tumor initiation, invasion in skin basal cell carcinoma.»

«We wanted to understand how a long - term high - fat diet influences the biology of stem cells, and how such diet - induced changes that occur in stem cells impact tumor initiation in the intestine,» Yilmaz says.

Intraperitoneal injection of the HIF - 1α inhibitor, YC1, following tumor initiation reduces the hypoxic CSC effect in MCF7 xenografts and results in no correlation between xenograft size and MFC (Fig. 5C).

«Taken together, our findings indicate that loss of Notch1 significantly reduced K - ras lung tumor initiation and overall tumor burden,» the researchers wrote.

Three weeks later, there was no detectable difference in tumor frequency or burden between Atg7 - intact or Atg7 - deleted mice, suggesting that autophagy may not be required for tumor initiation in this case.

Cancer stem - like cells (CSC) are a minor population of tumor mass and considered to have abilities of tumor initiation, differentiation, and chemoresistance (1).

In cancer, it is generally accepted that autophagy can suppress tumor initiation.

Further studies showed that Notch1 knockdown in NSCLC helps induce cell death (which inhibits tumor initiation and growth); this process is mediated by p53, and thus the effects of inhibiting Notch1 require functional p53.

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

«These new findings not only demonstrate the importance of the cancer cell of origin in controlling breast tumor heterogeneity, but also show that the gene expression signature found in the early steps of tumor initiation is predictive of the type of tumors that will eventually develop and the clinical prognosis of women with breast cancers» comments Cédric Blanpain, the senior author of the Nature paper.

Alternations in the pathway are believed to play an early role in tumor initiation and progression.

«If the CD117 cell population does lead to tumor initiation or cancer reoccurrence, this cell marker could become a therapeutic target,» she says.

Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Together, results from established assays for CSC activity show that the cycling hypoxia - selected subpopulation has an increased ability of tumor initiation and tumor - sphere formation.

Aside from their role in tumor initiation, stem - like cancer cells have been hypothesized to contribute directly to cancer metastasis.

This subpopulation of tumor cells, believed to be responsible for tumor initiation and progression, is often resistant to present therapeutic regimens including chemotherapy and radiation therapy and most likely involved in disease dissemination.

Altogether, our study shows that fascin can promote tumor progression in vivo, but also unravels an unexpected role of fascin in tumor initiation.

First, the researchers used a cell model of adenocarcinoma to test which of the Notch receptors are required for tumor initiation; after observing a «dramatic decrease in cell numbers» only with Notch1 knockdown, they began a mouse study involving inhibition of Notch1.